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Cremophor EL

Synonyms: CrEL

Cremophor EL, a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). Cremophor EL is used in severe anaphylactoid hypersensitivity reactions, hyperlipidaemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy.

Cremophor EL Chemical Structure

Cremophor EL Chemical Structure

CAS No. 61791-12-6

Purity & Quality Control

Cremophor EL Related Products

Biological Activity

Description Cremophor EL, a polyethoxylated surfactant, is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). Cremophor EL is used in severe anaphylactoid hypersensitivity reactions, hyperlipidaemia, abnormal lipoprotein patterns, aggregation of erythrocytes and peripheral neuropathy.
In vitro
In vitro

Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL in concentrations corresponding to clinical doses causes endothelial and epithelial toxicity. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment.[1]
Cell Research Cell lines Human cell lines brain microvascular endothelial, Caco-2 cells
Concentrations 0.1-50 mg/ml
Incubation Time 24 h
Method

Cell lines are seeded in culture dishes at a density of 5 × 104 cells/cm2, and the medium is changed every 2 days. Cremophor EL are tested at 0.1–50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death.
In Vivo
In vivo

Cremophor EL-BB4 formulation-mediated photodynamic therapy (PDT) disseminated cancer in CT26-Luc mouse colon carcinoma model of intraperitoneal (IP) and significantly prolonged survival in mice when used along with white light.

Chemical Information & Solubility

Molecular Weight Formula
CAS No. 61791-12-6 SDF --
Density 1.05 g/mL at 20 °C
Smiles C(C(CCl)OC(=O)N)Cl
Storage (From the date of receipt) 2 years -20°C(in the dark) liquid

In vitro
Batch:


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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