N-Acetylneuraminic acid

Name: N-Acetylneuraminic acid
Brand: Selleck Chemicals
SKU: S4792
Rating: 5 (2 reviews)

Synonyms: Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid

Catalog No.S4792 Purity:99.82%

N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.

N-Acetylneuraminic acid Chemical Structure

CAS No. 131-48-6

Purity & Quality Control

Batch: Purity: 99.82%

99.82

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.

In Vivo
In vivo	N-Acetylneuraminic acid (Neu5Ac) could improve lipid metabolism and hyperlipidemia-associated coagulation. It prevents HFD-induced hypercholesterolemia and hypercoagulation through regulation of serum lipid levels, metabolic indices, and coagulation-related indices^[2].
Animal Research	Animal Models	Sprague-Dawley rats
	Dosages	20 mg/kg
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT03545568	Completed	N-Acetylneuraminic Acid Storage Disease	University of Lausanne\|University of Modena and Reggio Emilia	May 1 2018	Not Applicable
NCT02346461	Completed	GNE Myopathy	National Human Genome Research Institute (NHGRI)\|National Center for Advancing Translational Sciences (NCATS)\|National Institutes of Health Clinical Center (CC)	February 5 2015	Phase 2
NCT01236898	Completed	Nonaka Myopathy\|Hereditary Inclusion Body Myopathy	Tohoku University	November 2010	Phase 1

References

Chemical Information & Solubility

Molecular Weight	309.27	Formula	C₁₁H₁₉NO₉
CAS No.	131-48-6	SDF	Download N-Acetylneuraminic acid SDF
Smiles	CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 62 mg/mL ( (200.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 62 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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