Sclareol

Name: Sclareol
Brand: Selleck Chemicals
SKU: S2354
Rating: 5 (1 reviews)

Catalog No.S2354 Purity:99.59%

Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.

Sclareol Chemical Structure

CAS No. 515-03-7

Purity & Quality Control

Batch: Purity: 99.59%

99.59

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Biological Activity

Description	Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.

In vitro
In vitro	Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts antitumor effects in various cell lines. Sclareol is able to inhibit DNA synthesis induce arrest at the G(0/1) phase of the cycle apoptosis independent of p53 in human breast cancer cell lines. ^[1] Intra-tumoral injection of Sclareol reduces tumor growth in vivo against breast cancer. ^[2] Sclareol also exhibits anti-inflammatory activity in LPS-stimulated macrophages by decreasing inflammatory cytokines expression and increasing antioxidant enzyme activity. ^[3]

In Vivo
In vivo	LD50: Rats >5g/kg (i.g.) ^[4]

References

[4] Sashidhara KV, et al. Phytother Res, 2007, 21(11), 1105-1108.

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Chemical Information & Solubility

Molecular Weight	308.5	Formula	C₂₀H₃₆O₂
CAS No.	515-03-7	SDF	Download Sclareol SDF
Density	g/mL
Smiles	CC1(CCCC2(C1CCC(C2CCC(C)(C=C)O)(C)O)C)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 41 mg/mL ( (132.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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