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Technical Data
| Formula | C20H36O2 |
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| Molecular Weight | 308.5 | CAS No. | 515-03-7 | |
| Solubility (25°C)* | In vitro | DMSO | 41 mg/mL (132.9 mM) | |
| Ethanol | 20 mg/mL (64.82 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines. | |||||
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| In vitro | Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts antitumor effects in various cell lines. Sclareol is able to inhibit DNA synthesis induce arrest at the G(0/1) phase of the cycle apoptosis independent of p53 in human breast cancer cell lines. [1] Intra-tumoral injection of Sclareol reduces tumor growth in vivo against breast cancer. [2] Sclareol also exhibits anti-inflammatory activity in LPS-stimulated macrophages by decreasing inflammatory cytokines expression and increasing antioxidant enzyme activity. [3] | |||||
| In vivo | LD50: Rats >5g/kg (i.g.) [4] | |||||
| Density | g/mL | |||||
Protocol (from reference)
References
Customer Product Validation
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Data from [Data independently produced by , , Cytotechnology, 2016, 68(4):1633-40]
Selleck's Sclareol has been cited by 1 publication
| Cell-based assay system for high-throughput screening of anti-photo-aging agents in fibroblast transfectants. [Lee S, et al. Cytotechnology, 2016, 68(4):1633-40] | PubMed: 26281901 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.