Home Others Others Sodium Picosulfate For research use only.

Sodium Picosulfate

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

Sodium Picosulfate Chemical Structure

Sodium Picosulfate Chemical Structure

CAS No. 10040-45-6

Purity & Quality Control

Batch: S402001 DMSO]96 mg/mL]false]Water]96 mg/mL]false]Ethanol]3 mg/mL]false Purity: 99.69%
99.69

Sodium Picosulfate Related Products

Biological Activity

Description Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
In vitro
In vitro Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1]
In Vivo
In vivo Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. [2] Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. [3] Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04113382 Recruiting
Bowel Preparation
Ferring Pharmaceuticals
 June 23 2022 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 481.41 Formula

C18H15NO8S2.2Na
CAS No. 10040-45-6 SDF Download Sodium Picosulfate SDF
Smiles C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 96 mg/mL ( (199.41 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 96 mg/mL

Ethanol : 3 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Sodium Picosulfate | Sodium Picosulfate ic50 | Sodium Picosulfate price | Sodium Picosulfate cost | Sodium Picosulfate solubility dmso | Sodium Picosulfate purchase | Sodium Picosulfate manufacturer | Sodium Picosulfate research buy | Sodium Picosulfate order | Sodium Picosulfate mouse | Sodium Picosulfate chemical structure | Sodium Picosulfate mw | Sodium Picosulfate molecular weight | Sodium Picosulfate datasheet | Sodium Picosulfate supplier | Sodium Picosulfate in vitro | Sodium Picosulfate cell line | Sodium Picosulfate concentration | Sodium Picosulfate nmr