Sucralose

Name: Sucralose
Brand: Selleck Chemicals
SKU: S4214
Rating: 5 (1 reviews)

Synonyms: E955,Trichloro Sucrose

Catalog No.S4214 Purity:100.0%

Sucralose (E955,Trichloro Sucrose) is an artificial and noncaloric sweetener, not broken down by the body.

Sucralose Chemical Structure

CAS No. 56038-13-2

Purity & Quality Control

Batch: S421401 DMSO]80 mg/mL]false]Water]80 mg/mL]false]Ethanol]Insoluble]false Purity: 100.0%

100.0

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Biological Activity

Description	Sucralose (E955,Trichloro Sucrose) is an artificial and noncaloric sweetener, not broken down by the body.

In vitro
In vitro	Combining pea with sucrose and sucralose induced even higher levels of CCK and GLP-1. Synchronous addition of pea and sucralose to enteroendocrine cells induced higher levels of CCK and GLP-1 than addition of each compound alone.

In Vivo
In vivo	Effects of sucralose sweetener on blood constituents labelled with technetium-99m ((99m)Tc) on red blood cell (RBC) morphology, sodium pertechnetate (Na(99m)TcO(4)) and diethylenetriaminepentaacetic acid labeled with (99m)Tc ((99m)Tc-DTPA) biodistribution in rats are evaluated. There is no alteration on RBC blood constituents and morphology %ATI. Sucralose sweetener is capable of altering %ATI/g of the radiopharmaceuticals in different organs. These findings are associated to the sucralose sweetener in specific organs.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05124886	Recruiting	Enteric Hyperoxaluria	NYU Langone Health\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	November 10 2022	Not Applicable
NCT05579392	Recruiting	Inflammatory Bowel Disease	Rush University Medical Center	September 22 2022	Not Applicable
NCT05379270	Active not recruiting	Breastfeeding	George Washington University	February 28 2022	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	397.63	Formula	C₁₂H₁₉Cl₃O₈
CAS No.	56038-13-2	SDF	Download Sucralose SDF
Smiles	C(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 80 mg/mL ( (201.19 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 80 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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