Spermine

Name: Spermine
Brand: Selleck Chemicals
SKU: S3948
Rating: 5 (3 reviews)

Synonyms: 4,9-Diaza-1,12-dodecanediamine

Catalog No.S3948 Purity:99.4%

Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria.

Spermine Chemical Structure

CAS No. 71-44-3

Purity & Quality Control

Batch: Purity: 99.4%

99.4

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria.

In vitro
In vitro	Spermidine and spermine significantly increases the viability and proliferation of SKOV-3 cells in a time-dependent manner, and decreases the apoptotic effect of Difluoromethylornithine (DFMO) in SKOV-3 cells. ^[1]
Cell Research	Cell lines	SKOV-3 cells
	Concentrations	50 μM
	Incubation Time	1–5 days
	Method	SKOV-3 cells are incubated with 50 μM spermidine or spermine for 1–5 days, and then cell viability and proliferation are determined using the PrestoBlue or CellTiter-Glo assays, respectively.

In Vivo
In vivo	Pretreatment with SPM significantly alleviated liver injury and reduced intrahepatic inflammation in thioacetamide (TAA)-induced liver injury compared to controls.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04339920	Withdrawn	Prostate Cancer	Chinese University of Hong Kong	September 1 2021	--
NCT03914391	Recruiting	Prostate Cancer	Chinese University of Hong Kong	January 16 2019	--
NCT04960956	Terminated	Prostate Cancer\|Urothelial Carcinoma	Indiana University	October 13 2016	--
NCT02855918	Completed	Major Depression	University Hospital Montpellier\|Institut National de la Santé Et de la Recherche Médicale France\|Sys2Diag Mixt laboratory CNRS/Alcediag Montpellier	September 23 2016	Not Applicable

References

[1] Hwang WY, et al. Int J Mol Sci. 2021 Sep 23;22(19):10255.

Chemical Information & Solubility

Molecular Weight	202.34	Formula	C₁₀H₂₆N₄
CAS No.	71-44-3	SDF	Download Spermine SDF
Smiles	C(CCNCCCN)CNCCCN
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 40 mg/mL ( (197.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 40 mg/mL

Ethanol : 40 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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