Home Others Other chemical 4-HNE (4-Hydroxynonenal) For research use only.

4-HNE (4-Hydroxynonenal)

Synonyms: HNE, 4-hydroxy Nonenal, 4-hydroxy-2-nonenal

4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.

4-HNE (4-Hydroxynonenal) Chemical Structure

4-HNE (4-Hydroxynonenal) Chemical Structure

CAS No. 75899-68-2

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4-HNE (4-Hydroxynonenal) Related Products

Biological Activity

Description 4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.
In vitro
In vitro

4-Hydroxynonenal (4-HNE) is one of the main end products of lipid peroxidation,  which induces the expression of heme oxygenase-1 (HO-1), peroxiredoxin-1 and stress protein A170 in an Nrf2-dependent manner in murine macrophages.<sup><a class="sref" href="#s_ref">[2]</a></sup>
Cell Research Cell lines Mouse Peritoneal Macrophages
Concentrations 10 μM
Incubation Time 24 h
Method

Oil Red O Staining: Mouse peritoneal macrophages were incubated for 24 h at 37℃ in 5% CO2 in PRMI 1640 medium containing 10% FCS in the absence or presence of 4-Hydroxynonenal (4-HNE) (10 μM) or moxLDL or oxLDL (200 μg protein/ml). Cells were washed twice, fixed in formalin, and stained with oil red O. The area of lipid-loaded macrophages was measured using a computerized MacSCOPE image analysis system.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06126315 Not yet recruiting
Amyotrophic Lateral Sclerosis
Mario Negri Institute for Pharmacological Research|University of Sydney|FightMND
 June 2024 Phase 2|Phase 3
NCT05742698 Active not recruiting
Frontotemporal Dementia|Frontotemporal Dementia Behavioral Variant|Primary Progressive Aphasia|bvFTD|PPA|FTD
Simon Ducharme MD|Alzheimer''s Drug Discovery Foundation|Douglas Mental Health University Institute
 March 7 2023 Phase 2
NCT05829382 Active not recruiting
Healthy Aging
Helse Stavanger HF
 March 15 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 156.22 Formula

C9H16O2
CAS No. 75899-68-2 SDF --
Density 0.9 g/mL
Storage (From the date of receipt) 2 years -20°C liquid

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