Polyinosinic acid-polycytidylic acid

Name: Polyinosinic acid-polycytidylic acid
Brand: Selleck Chemicals
SKU: E0518
Rating: 5 (1 reviews)

Synonyms: Polyinosinic-polycytidylic acid; Poly(I:C)

Catalog No.E0518 Purity:98%

Polyinosinic acid-polycytidylic acid (Polyinosinic-polycytidylic acid; Poly(I:C)), a double-stranded RNA that induces innate immunity in mammals, is a candidate immunopotentiator for pharmaceuticals. Polyinosinic acid-polycytidylic acid is dsRNA formed by the long chain decomposition of muscle poly (I) homopolymer into poly (C) homopolymer.

Polyinosinic acid-polycytidylic acid Chemical Structure

CAS No. 24939-03-5

Purity & Quality Control

Batch: Purity: 98%

Polyinosinic acid-polycytidylic acid Related Products

Related Products	BAPTA-AM Rat IgG2b isotype control-InVivo Blebbistatin Methyl-β-cyclodextrin (MβCD) AP-III-a4 (ENOblock) Carbazochrome sodium sulfonate (AC-17) Ursolic Acid Osthole NAD+ 4-Methylumbelliferone (4-MU) Dioscin Ethidium bromide Pitstop 2 Sesamin Bilobalide Formononetin Hesperidin Palmitic acid Azeliragon (TTP488) L-Mimosine Ademetionine Carbenoxolone Sodium GO-203 Vitexin N6022 Dp44mT Chlorogenic Acid Sphingosine Chrysin Coenzyme Q10 (CoQ10) Spermine Tetrahydrochloride 2-NBDG 2-NBDG D-Lin-MC3-DMA (MC3) Morin Hydrate Ethylenediaminetetraacetic acid Silibinin (NSC 651520) (+)-Fangchinoline Bergenin Spermine NB 598 DMNQ (20S)Ginsenoside Rg2 Farrerol EGCG Octaacetate D-(+)-Trehalose dihydrate Reboxetine mesylate E7820 Hydroxytyrosol Evofosfamide (TH-302) Bromhexine HCl 5-hydroxytryptophan (5-HTP) Inosine D-Mannose Anethole trithione Sodium Nitroprusside Dihydrate Alendronic Acid 2,4-Pyridinedicarboxylic acid GSK805 ADP Acipimox Curcumin analog C1 Trimetazidine 2,2,2-Tribromoethanol Sulfopin N-Acetylneuraminic acid Quinacrine Dihydrochloride Dihydrate L-methionine Stigmasterol Oleanonic Acid Substance P TFA Achyranthes bidentata root Extract Ginsenoside Rg3 Phyllanthus Urinaria Extract NSI-189 SR8278 Lycopene Trometamol hydrochloride 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) Ureidosuccinic acid Tea polyphenol Fructose (+)-JQ1 carboxylic acid Ligustilide Polybrene (Hexadimethrine Bromide) Pinoresinol diglucoside 4-HNE (4-Hydroxynonenal) Iron Dextran Sodium Picosulfate IM-54 Disufenton sodium Troxipide Orcinol glucoside Diludine 20R-Camptothecin (+)-Usniacin 3-Indolebutyric acid (IBA) HEPES Cremophor EL BMS-986176 DTT (Dithiothreitol) Esculin Methyl Eugenol L-(-)-Glucose 1-Hydroxy-2-naphthoic acid Azomycin 3-Hydroxybenzoic acid Emlenoflast (MCC-7840) β-Alanine β-Sitosterol Rat IgG1 isotype control-InVivo Aminomalonic acid Helecin BRM/BRG1 ATP Inhibitor-1 23-Hydroxybetulinic acid PZ-2891 Toosendanin 1,2-Propanediol Epibrassinolide Cyanidin-3-O-glucoside chloride Dihydrotanshinone I Gracillin Sodium Pyruvate Itaconic acid FH1 Cinnamic acid Guanidine HCl Triethylenetetramine 2HCl Molsidomine Calcium D-saccharate tetrahydrate Creatine monohydrate DL-Dopa FPH1 5'-Adenylic acid Acetamide ML329 Pterostilbene Kinetin Acetyl Resveratrol GSK4112 LTI-291 Plantamajoside Anhydroicaritin BZ1 Phloretic acid Anemoside B4 EGTA Sucralose 6-Chloropurine Glucosamine hydrochloride Sinoacutine 2,4-Dihydroxyacetophenone Stearic acid Stevioside Morin PMPA tetrasodium salt L-Hydroorotic acid Irigenin Behenic Acid CTX-0294885 Fudosteine (R)-(-)-JQ1 Enantiomer 2'-Deoxyguanosine monohydrate L-Tryptophanamide Hydrochloride β-Cyclodextrin 3-Indolepropionic acid DL-Citrulline Sclareol Methyl protocatechuate Sodium nitroprusside N-Nitrosodiethylamine Deoxyaconitine N-Acetyl-L-methionine Sinapine thiocyanate Sodium succinate Senkyunolide A L-Tryptophan Swertiamarin Octyl gallate Brassinazole	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ Express-Pick Library	Click to Expand

Biological Activity

Description	Polyinosinic acid-polycytidylic acid (Polyinosinic-polycytidylic acid; Poly(I:C)), a double-stranded RNA that induces innate immunity in mammals, is a candidate immunopotentiator for pharmaceuticals. Polyinosinic acid-polycytidylic acid is dsRNA formed by the long chain decomposition of muscle poly (I) homopolymer into poly (C) homopolymer.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT02423863	Completed	Melanoma\|Head and Neck Cancer\|Sarcoma\|Non-Melanoma Skin Cancers	Oncovir Inc.\|National Institutes of Health (NIH)\|Icahn School of Medicine at Mount Sinai\|Bay Hematology Oncology\|National Cancer Institute (NCI)\|University of Missouri-Columbia\|Chevy Chase Regional Cancer Care Associates LLC\|Dermatologic Surgery Center of Washington LLC and Skin Cancer Treatment Center	March 2015	Phase 2
NCT01727895	Completed	Immunologic Deficiency Syndromes	Radboud University Medical Center	May 2013	Not Applicable

References

[1] Nakano T, et al. Biosci Biotechnol Biochem. 2018 Nov;82(11):1889-1901.

Chemical Information & Solubility

Molecular Weight	671.40	Formula	C₁₉H₂₇N₇O₁₆P₂
CAS No.	24939-03-5	SDF	--
Smiles	NC1=NC(=O)N(C=C1)C2OC(CO[P;v5](O)(O)=O)C(O)C2O.OC3C(O)C(OC3CO[P;v5](O)(O)=O)[N]4C=NC5=C4NC=NC5=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Tags: buy Polyinosinic acid-polycytidylic acid | Polyinosinic acid-polycytidylic acid supplier | purchase Polyinosinic acid-polycytidylic acid | Polyinosinic acid-polycytidylic acid cost | Polyinosinic acid-polycytidylic acid manufacturer | order Polyinosinic acid-polycytidylic acid | Polyinosinic acid-polycytidylic acid distributor

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):