Polyinosinic acid-polycytidylic acid

Name: Polyinosinic acid-polycytidylic acid
Brand: Selleck Chemicals
SKU: E0518
Rating: 5 (1 reviews)

Synonyms: Polyinosinic-polycytidylic acid; Poly(I:C)

Catalog No.E0518 Purity:98%

Polyinosinic acid-polycytidylic acid (Polyinosinic-polycytidylic acid; Poly(I:C)), a double-stranded RNA that induces innate immunity in mammals, is a candidate immunopotentiator for pharmaceuticals. Polyinosinic acid-polycytidylic acid is dsRNA formed by the long chain decomposition of muscle poly (I) homopolymer into poly (C) homopolymer.

Polyinosinic acid-polycytidylic acid Chemical Structure

CAS No. 24939-03-5

Purity & Quality Control

Batch: Purity: 98%

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	Polyinosinic acid-polycytidylic acid (Polyinosinic-polycytidylic acid; Poly(I:C)), a double-stranded RNA that induces innate immunity in mammals, is a candidate immunopotentiator for pharmaceuticals. Polyinosinic acid-polycytidylic acid is dsRNA formed by the long chain decomposition of muscle poly (I) homopolymer into poly (C) homopolymer.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT02423863	Completed	Melanoma\|Head and Neck Cancer\|Sarcoma\|Non-Melanoma Skin Cancers	Oncovir Inc.\|National Institutes of Health (NIH)\|Icahn School of Medicine at Mount Sinai\|Bay Hematology Oncology\|National Cancer Institute (NCI)\|University of Missouri-Columbia\|Chevy Chase Regional Cancer Care Associates LLC\|Dermatologic Surgery Center of Washington LLC and Skin Cancer Treatment Center	March 2015	Phase 2
NCT01727895	Completed	Immunologic Deficiency Syndromes	Radboud University Medical Center	May 2013	Not Applicable

References

[1] Nakano T, et al. Biosci Biotechnol Biochem. 2018 Nov;82(11):1889-1901.

Chemical Information & Solubility

Molecular Weight	671.40	Formula	C₁₉H₂₇N₇O₁₆P₂
CAS No.	24939-03-5	SDF	--
Smiles	NC1=NC(=O)N(C=C1)C2OC(CO[P;v5](O)(O)=O)C(O)C2O.OC3C(O)C(OC3CO[P;v5](O)(O)=O)[N]4C=NC5=C4NC=NC5=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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