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Glucosamine hydrochloride

Synonyms: 2-Amino-2-deoxy-glucose HCl, Chitosamine HCl

Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.

Glucosamine hydrochloride Chemical Structure

Glucosamine hydrochloride Chemical Structure

CAS No. 66-84-2

Purity & Quality Control

Batch: S369401 Water]43 mg/mL]false]DMSO]4 mg/mL]false]Ethanol]Insoluble]false Purity: 98.4%
98.4

Glucosamine hydrochloride Related Products

Biological Activity

Description Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
In vitro
In vitro Glucosamine enters the hexosamine biosynthetic pathway (HBP) downstream of the rate-limiting step catalyzed by the GFAT (glutamine:fluctose-6-phosphate amidotransferase), providing UDP-GlcNAc substrates for O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification. Glucosamine inhibits proteasomal activity and the proliferation of ALVA41 prostate cancer cells. The inhibition of proteasomal activity results in the accumulation of ubiquitinated proteins, followed by induction of apoptosis. Glucosamine downregulates proteasome activator PA28γ and overexpression of PA28γ rescues the proteasomal activity and growth inhibition mediated by glucosamine[1]. Glucosamine inhibits the proliferation of RCC cells by promoting cell cycle arrest at G0/G1 phase, but not promoting apoptosis[2].
Cell Research Cell lines ALVA41 cells
Concentrations 0-2 mM
Incubation Time 24 h
Method ALVA41 cells are treated with various concentrations of glucosamine (GlcN) for 24 h, and cell viability is analyzed using MTT assay.
In Vivo
In vivo Glucosamine could significantly inhibit the production of nitric oxide and prostagladin E2 and suppress the progression of adjuvant arthritis in rats. Glucosamine may be expected as a novel anti-inflammatory agent for treatment of rheumatoid arthritis. Administration of glucosamine normalizes cartilage metabolism, so as to inhibit the degradation and stimulate the synthesis of proteoglycans, and to restore the articular function. Glucosamine has been demonstrated to prolong the allogeneic cardiac allograft survival by repressing the activation of T-lymphoblasts and dendritic cells[3].
Animal Research Animal Models Male Wistar rats
Dosages 300 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 215.63 Formula

C6H13NO5.HCl
CAS No. 66-84-2 SDF Download Glucosamine hydrochloride SDF
Smiles C(C1C(C(C(C(O1)O)N)O)O)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 43 mg/mL

DMSO : 4 mg/mL ( (18.55 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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