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Technical Data
| Formula | C6H13NO5.HCl |
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| Molecular Weight | 215.63 | CAS No. | 66-84-2 | |
| Solubility (25°C)* | In vitro | Water | 43 mg/mL (199.41 mM) | |
| DMSO | 4 mg/mL (18.55 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. |
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| In vitro | Glucosamine enters the hexosamine biosynthetic pathway (HBP) downstream of the rate-limiting step catalyzed by the GFAT (glutamine:fluctose-6-phosphate amidotransferase), providing UDP-GlcNAc substrates for O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification. Glucosamine inhibits proteasomal activity and the proliferation of ALVA41 prostate cancer cells. The inhibition of proteasomal activity results in the accumulation of ubiquitinated proteins, followed by induction of apoptosis. Glucosamine downregulates proteasome activator PA28γ and overexpression of PA28γ rescues the proteasomal activity and growth inhibition mediated by glucosamine[1]. Glucosamine inhibits the proliferation of RCC cells by promoting cell cycle arrest at G0/G1 phase, but not promoting apoptosis[2]. |
| In vivo | Glucosamine could significantly inhibit the production of nitric oxide and prostagladin E2 and suppress the progression of adjuvant arthritis in rats. Glucosamine may be expected as a novel anti-inflammatory agent for treatment of rheumatoid arthritis. Administration of glucosamine normalizes cartilage metabolism, so as to inhibit the degradation and stimulate the synthesis of proteoglycans, and to restore the articular function. Glucosamine has been demonstrated to prolong the allogeneic cardiac allograft survival by repressing the activation of T-lymphoblasts and dendritic cells[3]. |
Protocol (from reference)
| Cell Assay:[1] |
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| Animal Study:[3] |
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References
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Selleck's Glucosamine hydrochloride has been cited by 1 publication
| Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism. [ EBioMedicine, 2019, 39:540-551] | PubMed: 30578080 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.