Molsidomine

Name: Molsidomine
Brand: Selleck Chemicals
SKU: S4664
Rating: 5 (2 reviews)

Synonyms: SIN-10, Corvaton, Morsydomine

Catalog No.S4664 Purity:99.92%

Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

Molsidomine Chemical Structure

CAS No. 25717-80-0

Purity & Quality Control

Batch: Purity: 99.92%

99.92

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Biological Activity

Description	Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

In Vivo
In vivo	Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart^[1].
Animal Research	Animal Models	Adult mongrel dogs
	Dosages	50, 100, 250 μg/kg
	Administration	i.v.

References

[1] Volker B. Fiedler, et al. Naunyn-Schmiedeberg's Archives of Pharmacology. 1981, 317(1):71-77.

Chemical Information & Solubility

Molecular Weight	242.23	Formula	C₉H₁₄N₄O₄
CAS No.	25717-80-0	SDF	Download Molsidomine SDF
Smiles	CCOC(=NC1=C[N+](=NO1)N2CCOCC2)[O-]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 49 mg/mL ( (202.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 24 mg/mL

Ethanol : 24 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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