Sodium Nitroprusside Dihydrate

Name: Sodium Nitroprusside Dihydrate
Brand: Selleck Chemicals
SKU: S4059
Rating: 5 (2 reviews)

Catalog No.S4059 Purity:99.7%

Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

Sodium Nitroprusside Dihydrate Chemical Structure

CAS No. 13755-38-9

Purity & Quality Control

Batch: S405901 DMSO]60 mg/mL]false]Water]60 mg/mL]false]Ethanol]Insoluble]false Purity: 99.7%

99.7

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Biological Activity

Description

Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

Targets

guanylate cyclase ^[1]

In vitro
In vitro	Sodium Nitroprusside is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate. ^[1] Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells. ^[2]

In Vivo
In vivo	Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats. ^[3]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05277922	Completed	Study Vasodilatory Effects of C21	Vicore Pharma AB\|CTC Clinical Trial Consultants AB	April 28 2022	Phase 1
NCT04303689	Completed	Essential Hypertension	University of Copenhagen\|University of Aarhus	August 1 2020	Not Applicable
NCT04321434	Terminated	Coronary Microvascular Disease\|Microvascular Disease\|Ischemic Heart Disease	Université Libre de Bruxelles	December 1 2016	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	297.95	Formula	C₅H₄FeN₆Na₂O₃
CAS No.	13755-38-9	SDF	--
Smiles	[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[N-]=O.O.O.[Na+].[Na+].[Fe+4]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 60 mg/mL ( (201.37 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 60 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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