L-Tryptophan

Catalog No.S3987 Batch:S398701

Technical Data

Formula	C₁₁H₁₂N₂O₂
Molecular Weight	204.23	CAS No.	73-22-3
Solubility (25°C)*	In vitro	DMSO	11 mg/mL (53.86 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.
In vivo	L-Tryptophan suppresses both serum glucose and insulin levels after oral glucose administration and inhibits glucose absorption from the intestine. It increases glucose-associated energy expenditure in rats in vivo. L-Tryptophan suppresses the rapid rise in blood glucose after a glucose-rich meal and lessens the burden of insulin secretion from β-cells. Oral administration of L-tryptophan is more effective than intraperitoneal injection^[1].

Description

L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.

In vivo

L-Tryptophan suppresses both serum glucose and insulin levels after oral glucose administration and inhibits glucose absorption from the intestine. It increases glucose-associated energy expenditure in rats in vivo. L-Tryptophan suppresses the rapid rise in blood glucose after a glucose-rich meal and lessens the burden of insulin secretion from β-cells. Oral administration of L-tryptophan is more effective than intraperitoneal injection^[1].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models Four-week-old male normal Sprague-Dawley rats Dosages 62.5 mg/kg Administration Oral administration

References

[1] Tomoko Inubushi, et al. J Nutr Sci Vitaminol. 2012, 58:415-422.

Selleck's L-Tryptophan has been cited by 1 publication

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation [ Proc Natl Acad Sci U S A, 2022, 119(47):e2208886119]	PubMed: 36375056

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation [ Proc Natl Acad Sci U S A, 2022, 119(47):e2208886119]

PubMed: 36375056

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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