Lycopene

Catalog No.S3943 Batch:S394301

Technical Data

Formula	C₄₀H₅₆
Molecular Weight	536.87	CAS No.	502-65-8
Solubility (25°C)*	In vitro	0.5MNAOH	3.03 mg/mL (5.64 mM)
		DMSO	Insoluble
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant., Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.
In vitro	Lycopene is found in nature in the all-trans form; however, thermal processing, as well as intestinal digestion, of raw tomato products facilitates its cis-isomerization^[3]. Lycopene is recognized to be the most efficient singlet oxygen quencher among biological carotenoids. Antioxidant functions are associated with lowering DNA damage, malignant transformation, and reducing biological oxidative damage of proteins, lipids, and other cell components in vitro. Lycopene has also been found to increase gap-junctional communication between cells and to induce the synthesis of connexin-43^[1]. It negatively affects cancer cells or development of cancer by modulating cell cycle progression and cell proliferation and has an inhibitory effect on DNA synthesis, initiating up-regulation of gap-junction proteins and a reduction of local androgen signaling, impact IGIF-1 signaling, antioxidant activity and induction of apoptotic cell death^[2].
In vivo	Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. It is found that the consumption of lycopene in fruits and vegetables may reduce the likelihood of developing heart disease. Lycopene prevents oxidation of low-density lipoprotein (LDL) cholesterol and reduces the risk of developing atherosclerosis and coronary heart disease. Lycopene is as effective as β-carotene in inhibiting the growth of the glioma cells in the model of glioma cells transplanted in rats^[1]. Lycopene acts as an antioxidant agent both through a decrease in intracellular reactive species production in vitro and in vivo through the neutralization of reactive species, the restoration of the GSH/GSSG ratio, decrease in oxidatively generated damage and decrease in proinflammatory cytokines through decreased cell influx as well as direct suppression of cytokine production^[3].

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines HT-29, T84 and MCF-7 cells Concentrations 1-5 μM Incubation Time 48 and 96 h Method Human cell lines are treated with lycopene (1-5 μM) for 48 and 96 h. Cell viability is monitored using the method of MTT. The cell cycle is analyzed by flow cytometry, and apoptotic cells are identified by terminal deoxynucleotidyl transferase-mediated dUTP nick labeling (TUNEL) and by DAPI.
Animal Study:^{^[3]}	Animal Models Male C57BL/6 mice Dosages 25 or 50 mg/kg/day Administration by orogastric gavage

Cell Assay:^{^[2]}

Cell lines
HT-29, T84 and MCF-7 cells
Concentrations
1-5 μM
Incubation Time
48 and 96 h
Method
Human cell lines are treated with lycopene (1-5 μM) for 48 and 96 h. Cell viability is monitored using the method of MTT. The cell cycle is analyzed by flow cytometry, and apoptotic cells are identified by terminal deoxynucleotidyl transferase-mediated dUTP nick labeling (TUNEL) and by DAPI.

Animal Study:^{^[3]}

Animal Models
Male C57BL/6 mice
Dosages
25 or 50 mg/kg/day
Administration
by orogastric gavage

References

Selleck's Lycopene has been cited by 1 publication

Enhancing regulatory T cell function via inhibition of high mobility group box 1 protein signaling in immune thrombocytopenia [ Haematologica, 2022, 10.3324/haematol.2022.281557]	PubMed: 36263841

Enhancing regulatory T cell function via inhibition of high mobility group box 1 protein signaling in immune thrombocytopenia [ Haematologica, 2022, 10.3324/haematol.2022.281557]

PubMed: 36263841

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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