Sesamin

Catalog No.S2392 Batch:S239202

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Technical Data

Formula

C20H18O6
Molecular Weight 354.35 CAS No. 607-80-7
Solubility (25°C)* In vitro DMSO 70 mg/mL (197.54 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.
In vitro Sesamin (Fagarol) is a lignan isolated from the bark of Fagara plants and from sesame oil. It has been used as a dietary fat-reduction supplement. Sesamin truly increases fat metabolism. Sesamin specifically inhibits delta 5 desaturase at low concentrations in polyunsaturated fatty acid biosynthesis in both microorganisms and animals, but does not inhibit delta 6, delta 9 and delta 12 desaturases. [1] Dietary sesamin greatly increases the hepatic activity of fatty acid oxidation enzymes, including carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, 3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and 3-ketoacyl-CoA thiolase. Dietary sesamin also increases the activity of 2,4-dienoyl-CoA reductase and delta3,delta2-enoyl-CoA isomerase, enzymes involved in the auxiliary pathway for beta-oxidation of unsaturated fatty acids dose-dependently. [2] Sesamin is also a novel inhibitor of pregnane X receptor (PXR) and may be useful for modulating CYP3A4 and drug efficacies. [3]
In vivo LD50: Mice 3800mg/kg (i.g.); Rats 6150mg/kg (i.g.) [4]

Protocol (from reference)

Selleck's Sesamin has been cited by 5 publications

Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex [ Neural Plast, 2023, 2023:5225952] PubMed: 36845359
Sesamin inhibits hypoxia-stimulated angiogenesis via the NF-κB p65/HIF-1α/VEGFA signaling pathway in human colorectal cancer [ Food Funct, 2022, 13(17):8989-8997] PubMed: 35939045
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation [ Mol Cell, 2020, 80(3):525-540.e9] PubMed: 33068521
Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway. [ Toxicol Appl Pharmacol, 2020, 387:114848] PubMed: 31809756
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] PubMed: 31595166

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.