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Technical Data
| Formula | C24H22N4O3 |
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| Molecular Weight | 414.46 | CAS No. | 1208315-24-5 | |
| Solubility (25°C)* | In vitro | DMSO | 82 mg/mL (197.84 mM) | |
| Ethanol | 5 mg/mL (12.06 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2. | ||||
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| Targets |
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| In vitro | N6022 shows limited off-target activity and low cytotoxicity toward A549 epithelial lung cells. [2] | ||||
| In vivo | N6022 (30 mg/kg iv or po) reduces bronchoconstriction and pulmonary inflammation in a mouse model of asthma. [2] |
Protocol (from reference)
| Animal Study:[2] |
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References
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Selleck's N6022 has been cited by 6 publications
| S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens [ Nat Commun, 2024, 15(1):1750] | PubMed: 38409248 |
| The role of S-nitrosoglutathione reductase (GSNOR) in T cell-mediated immunopathology of experimental autoimmune encephalomyelitis (EAE) [ Neuroscience, 2024, S0306-4522(24)00607-9] | PubMed: 39532197 |
| A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production [ Sci Adv, 2023, 9(20):eadg2235] | PubMed: 37196082 |
| Vitamin C deficiency induces hypoglycemia and cognitive disorder through S-nitrosylation-mediated activation of glycogen synthase kinase 3β [ Redox Biol, 2022, 56:102420] | PubMed: 35969998 |
| Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties [Barnett SD J Cell Mol Med, 2018, 22(12):6391-6395] | PubMed: 30188599 |
| S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor. [ Sci Rep, 2018, 8(1):5614] | PubMed: 29618799 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.