Sulfopin

Catalog No.S9782 Batch:S978201

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Technical Data

Formula

C11H20ClNO3S
Molecular Weight 281.80 CAS No. 2451481-08-4
Solubility (25°C)* In vitro DMSO 56 mg/mL (198.72 mM)
Ethanol 28 mg/mL (99.36 mM)
Water 3 mg/mL (10.64 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.
Targets
Pin1 [1]
(in the FP assay)
17 nM(Ki)
In vitro

Sulfopin is a highly selective covalent inhibitor of Pin1 (peptidyl-prolyl isomerase) due to target engagement and phenocopies Pin1 genetic knockout, with a Ki of 17 nM in Fluorescence polarization (FP) test.<sup><a class="sref" href="#s_ref">[1]</a></sup>
In vivo

Sulfopin induces downregulation of c-Myc target genes, and reduces tumor progression and confers survival benefit in vivo.<sup><a class="sref" href="#s_ref">[1]</a></sup>

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    PATU-8988T cells

  • Concentrations

    0.001-100 μM

  • Incubation Time

    14 h

  • Method

    Fluorescence polarization assay
Animal Study:

[1]
  • Animal Models

    Mouse

  • Dosages

    10, 20 mg/kg by o.g. over 2 days; 10, 20 or 40 mg/kg by i.p. for 2 weeks

  • Administration

    o.g., i.p.

Selleck's Sulfopin has been cited by 2 publications

Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia [ Nat Commun, 2023, 14(1):5414] PubMed: 37669931
Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia [ Nat Commun, 2023, 14(1):5414] PubMed: 37669931

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.