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Tyloxapol

Synonyms: Triton WR1339

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.

Tyloxapol Chemical Structure

Tyloxapol Chemical Structure

CAS No. 25301-02-4

Purity & Quality Control

Tyloxapol Related Products

Biological Activity

Description Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.
Targets
lipoprotein lipase [1]
In vitro
In vitro Tyloxapol is generally regarded as a safe stabilizer. In some studies, it is reported to causes cytotoxicity in epithelial and red blood cells, induces lysis of human Jurkat T-lymphoblasts and the apoptosis in RAW 264.7 murine macrophage-like cells and NIH/3T3 mouse fibroblast cells. These indications of cytotoxicity, however, do not reflect the in vivo use of Tyloxapol, since it is rarely used alone in clinical applications[3].
Cell Research Cell lines HEK293 cells
Concentrations 100 μg/ml
Incubation Time 48 h
Method HEK293 cells growing at 40% confluency are exposed to different test dispersions of SLP or their individual components for 48 h and observed the alterations in cellular morphology.
In Vivo
In vivo A single intravenous injection of tyloxapol at dose of 400mg/kg body weight shows three distinctive phases, sharp linear increment, slow linear increment and slow decrement of plasma lipids toward the basal levels[1]. The treatment of tyloxapol enhannces the pulmonary absorption of rh-insulin and increases the absorption of inhaled insulin in diabetic rats. It might significantly increase the hypoglycemic effect of intratracheally administered insulin in diabetic rats but does not change the LDH activity[2].
Animal Research Animal Models Albino (Wistar) male rats 
Dosages 400mg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight Formula

(C14H22O.C2H4O.CH2O)x
CAS No. 25301-02-4 SDF Download Tyloxapol SDF
Density 1.11 g/mL
Smiles CC(C)(C)CC(C)(C)C1=CC=C(C=C1)O.C=O.C1CO1
Storage (From the date of receipt) 2 year -80°C liquid

In vitro
Batch:

DMSO : 100 mg/mL ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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