Tyloxapol

Catalog No.S4578 Batch:S457804

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Technical Data

Formula

(C14H22O.C2H4O.CH2O)x
Molecular Weight CAS No. 25301-02-4
Solubility (25°C)* In vitro DMSO 100 mg/mL
Water 100 mg/mL
Ethanol 100 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.
Targets
lipoprotein lipase [1]
In vitro Tyloxapol is generally regarded as a safe stabilizer. In some studies, it is reported to causes cytotoxicity in epithelial and red blood cells, induces lysis of human Jurkat T-lymphoblasts and the apoptosis in RAW 264.7 murine macrophage-like cells and NIH/3T3 mouse fibroblast cells. These indications of cytotoxicity, however, do not reflect the in vivo use of Tyloxapol, since it is rarely used alone in clinical applications[3].
In vivo A single intravenous injection of tyloxapol at dose of 400mg/kg body weight shows three distinctive phases, sharp linear increment, slow linear increment and slow decrement of plasma lipids toward the basal levels[1]. The treatment of tyloxapol enhannces the pulmonary absorption of rh-insulin and increases the absorption of inhaled insulin in diabetic rats. It might significantly increase the hypoglycemic effect of intratracheally administered insulin in diabetic rats but does not change the LDH activity[2].
Density 1.11 g/mL

Protocol (from reference)

Cell Assay:[3]
  • Cell lines

    HEK293 cells

  • Concentrations

    100 μg/ml

  • Incubation Time

    48 h

  • Method

    HEK293 cells growing at 40% confluency are exposed to different test dispersions of SLP or their individual components for 48 h and observed the alterations in cellular morphology.
Animal Study:[1]
  • Animal Models

    Albino (Wistar) male rats 

  • Dosages

    400mg/kg

  • Administration

    i.v.

Selleck's Tyloxapol has been cited by 3 publications

Deciphering COVID-19 host transcriptomic complexity and variations for therapeutic discovery against new variants [ iScience, 2022, 25(10):105068] PubMed: 36093376
Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver [ Front Cell Dev Biol, 2022, 10:808140] PubMed: 35372326
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734] PubMed: 32511305

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.