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Tectoridin

Synonyms: Shekanin

Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.

Tectoridin Chemical Structure

Tectoridin Chemical Structure

CAS No. 611-40-5

Purity & Quality Control

Batch: S381801 DMSO]92 mg/mL]false]]]false]]]false Purity: 99.7%
99.7

Tectoridin Related Products

Biological Activity

Description Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.
In vitro
In vitro Tectoridin is known as a phytoestrogen. Tectoridin exerts its estrogenic effect mainly via the GPR30 and ERK-mediated rapid nongenomic estrogen signaling pathway. It bound poorly to estrogen receptor α. Tectoridin increased intracelluar cAMP accumulation and rapidly increased the phosphorylation of ERK1/2, but does not induce phosphorylation of ER α at Ser118[1].
Cell Research Cell lines MCF-7 human breast cancer cells
Concentrations 0-10 μM
Incubation Time 96 h
Method

MCF-7 cells (5 × 105) are seeded on 60 mm dishes with hormone-free experimental medium and incubated for 48 h at 37°C in order to synchronize the cells in the G0/G1 phase. The cells are then treated with experimental medium supplemented with various concentrations (0-10 μM) of genistein, tectorigenin and tectoridin for 96 h. The cell cycle was analyzed.
In Vivo
In vivo Tectoridin shows significant protective effect on hepatic steatosis induced by ethanol through the modulation of PPAR pathway and protection of mitochondrial injury[2].
Animal Research Animal Models Male C57BL/6 mice
Dosages 25, 50 and 100 mg/kg
Administration intragastrically

Chemical Information & Solubility

Molecular Weight 462.4 Formula

C22H22O11
CAS No. 611-40-5 SDF Download Tectoridin SDF
Smiles COC1=C(C=C2C(=C1O)C(=O)C(=CO2)C3=CC=C(C=C3)O)OC4C(C(C(C(O4)CO)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (198.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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