Tectoridin

Catalog No.S3818 Batch:S381801

Technical Data

Formula	C₂₂H₂₂O₁₁
Molecular Weight	462.4	CAS No.	611-40-5
Solubility (25°C)*	In vitro	DMSO	92 mg/mL (198.96 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.
In vitro	Tectoridin is known as a phytoestrogen. Tectoridin exerts its estrogenic effect mainly via the GPR30 and ERK-mediated rapid nongenomic estrogen signaling pathway. It bound poorly to estrogen receptor α. Tectoridin increased intracelluar cAMP accumulation and rapidly increased the phosphorylation of ERK1/2, but does not induce phosphorylation of ER α at Ser118^[1].
In vivo	Tectoridin shows significant protective effect on hepatic steatosis induced by ethanol through the modulation of PPAR pathway and protection of mitochondrial injury^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines MCF-7 human breast cancer cells Concentrations 0-10 μM Incubation Time 96 h Method MCF-7 cells (5 × 10⁵) are seeded on 60 mm dishes with hormone-free experimental medium and incubated for 48 h at 37°C in order to synchronize the cells in the G0/G1 phase. The cells are then treated with experimental medium supplemented with various concentrations (0-10 μM) of genistein, tectorigenin and tectoridin for 96 h. The cell cycle was analyzed.
Animal Study:^{^[2]}	Animal Models Male C57BL/6 mice Dosages 25, 50 and 100 mg/kg Administration intragastrically

Cell Assay:^{^[1]}

Cell lines
MCF-7 human breast cancer cells
Concentrations
0-10 μM
Incubation Time
96 h
Method
MCF-7 cells (5 × 10⁵) are seeded on 60 mm dishes with hormone-free experimental medium and incubated for 48 h at 37°C in order to synchronize the cells in the G0/G1 phase. The cells are then treated with experimental medium supplemented with various concentrations (0-10 μM) of genistein, tectorigenin and tectoridin for 96 h. The cell cycle was analyzed.

Animal Study:^{^[2]}

Animal Models
Male C57BL/6 mice
Dosages
25, 50 and 100 mg/kg
Administration
intragastrically

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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