Sucralfate

Synonyms: Sucrose octasulfate-aluminum complex

Sucralfate(Sucrose octasulfate-aluminum complex) is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.

Sucralfate Chemical Structure

Sucralfate Chemical Structure

CAS No. 54182-58-0

Purity & Quality Control

Sucralfate Related Products

Biological Activity

Description Sucralfate(Sucrose octasulfate-aluminum complex) is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.
In vitro
In vitro

Sucralfate may inhibit intestinal epithelial motility by sterically interfering with adhesion to collagen I[3]. It protects RGMl cells from acid- and pepsin-induced damage[4].

Cell Research Cell lines RGMl cells
Concentrations 0.1, 0.3, 1, 3 mg/mL
Incubation Time 0.5-4 h
Method

Sucralfate is dissolved or suspended in culture medium containing 20% FBS. Cells are incubated with the agent at 37°C under 5% CO2, in air for 0.5-4 h. In some cases, cells are treated with 10-5mol/L indomethacin for 4h before the addition of the agent to determine whether or not intracellular prostaglandins are involved in the protective mechanisms of sucralfate.

In Vivo
In vivo

The protective effects of sucralfate against ARC(acute radiation colitis) may be partially due to the supression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region[2].

Animal Research Animal Models C57BL/6J mice
Dosages 3, 30, or 300 mg/kg
Administration by gastric intubation
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04918758 Recruiting
Radiation Proctopathy
Manchester University NHS Foundation Trust|National Institute for Health Research United Kingdom
July 22 2021 Not Applicable
NCT04327869 Completed
Capsule Endoscopy
Changhai Hospital
November 3 2018 --

Chemical Information & Solubility

Molecular Weight 2086.74 Formula

C12H54Al16O75S8

CAS No. 54182-58-0 SDF Download Sucralfate SDF
Smiles C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Al].[Al].[Al].[Al].[Al].[Al].[Al].[Al]
Storage (From the date of receipt)

In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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