Sucralfate

Catalog No.S4670 Batch:S467001

Technical Data

Formula	C₁₂H₅₄Al₁₆O₇₅S₈
Molecular Weight	2086.74	CAS No.	54182-58-0
Solubility (25°C)*	In vitro	5%TFA	3.04 mg/mL (1.45 mM)
		DMSO	0.01 mg/mL (0.0 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Sucralfate(Sucrose octasulfate-aluminum complex) is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus.
In vitro	Sucralfate may inhibit intestinal epithelial motility by sterically interfering with adhesion to collagen I^[3]. It protects RGMl cells from acid- and pepsin-induced damage^[4].
In vivo	The protective effects of sucralfate against ARC(acute radiation colitis) may be partially due to the supression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region^[2].

Protocol (from reference)

Cell Assay:^{^[4]}	Cell lines RGMl cells Concentrations 0.1, 0.3, 1, 3 mg/mL Incubation Time 0.5-4 h Method Sucralfate is dissolved or suspended in culture medium containing 20% FBS. Cells are incubated with the agent at 37°C under 5% CO₂, in air for 0.5-4 h. In some cases, cells are treated with 10^-5mol/L indomethacin for 4h before the addition of the agent to determine whether or not intracellular prostaglandins are involved in the protective mechanisms of sucralfate.
Animal Study:^{^[1]}	Animal Models C57BL/6J mice Dosages 3, 30, or 300 mg/kg Administration by gastric intubation

Cell Assay:^{^[4]}

Cell lines
RGMl cells
Concentrations
0.1, 0.3, 1, 3 mg/mL
Incubation Time
0.5-4 h
Method
Sucralfate is dissolved or suspended in culture medium containing 20% FBS. Cells are incubated with the agent at 37°C under 5% CO₂, in air for 0.5-4 h. In some cases, cells are treated with 10^-5mol/L indomethacin for 4h before the addition of the agent to determine whether or not intracellular prostaglandins are involved in the protective mechanisms of sucralfate.

Animal Study:^{^[1]}

Animal Models
C57BL/6J mice
Dosages
3, 30, or 300 mg/kg
Administration
by gastric intubation

References

[4] Furukawa O, et al. J Gastroenterol Hepatol. 1997, 12(5):353-9.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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