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Procyanidin B1

Procyanidin B1, a natural polyphenolic compound that has antioxidant properties, inhibits Kv10.1 channel and suppresses the evolution of hepatoma.

Procyanidin B1 Chemical Structure

Procyanidin B1 Chemical Structure

CAS No. 20315-25-7

Purity & Quality Control

Batch: E024001 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.6%
99.6

Procyanidin B1 Related Products

Biological Activity

Description

Procyanidin B1, a natural polyphenolic compound that has antioxidant properties, inhibits Kv10.1 channel and suppresses the evolution of hepatoma.
Targets
Kv10.1 [1]
(in the Rb+ efflux assay)
10.38 μM
In vitro
In vitro

Procyanidin B1 is a polyphenolic flavonoid isolated from fruits and fruit juices, which inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells.[1]
Cell Research Cell lines THP1 cells
Concentrations 100 µg/mL
Incubation Time 18 h
Method

THP1 cells are treated for 18 h with 1 µg/mL LPS in the presence or absence of 100 µg/mL procyanidin B1. Total RNA is extracted from THP1 cells using the RNAiso Plus kit.  Isolated total RNA is  reverse transcribed using an RT master mix kit for 15 min at 37℃ and 5 s at 85℃. cDNAs are amplified using a 7500 Real-Time PCR System with sequence-specific primers for MD-2, TLR4, TRAF6, and NF-kB designed and synthesized by Takara Biotechnology.
In Vivo
In vivo

Procyanidin B1 selectively inhibits the Kv10.1 channel in a concentration-dependent manner, which significantly suppress the growth of the tumor (HepG2) with no side effect on the normal metabolismof the mice.[2]

Chemical Information & Solubility

Molecular Weight 578.52 Formula

C30H26O12
CAS No. 20315-25-7 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (172.85 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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