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Glycine

Synonyms: 2-Aminoacetic acid, Aminoacetic acid, Glycocoll

Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.

Glycine Chemical Structure

Glycine Chemical Structure

CAS No. 56-40-6

Purity & Quality Control

Glycine Related Products

Biological Activity

Description Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.
Targets
MT2 receptor [1] MT1 receptor [1]
9.8(pKi) 9.45(pKi)
In vitro
In vitro Glycine significantly increases the MG-63 cell proliferation in a dosedependent manner. Activity of alkaline phosphatase (ALP) and phosphorylation of extracellular-signal-regulated kinase are increased by glycine in MG-63 cells. Glycine also increases the BrdU-incorporation and Ki-67 mRNA expression in MCF-7 cells, induces the up-regulation of estrogen receptor-β mRNA expression and estrogen response element-luciferase activity in MG-63 and MCF-7 cells[2].
Cell Research Cell lines MG-63 osteoblast cell line, MCF-7 estrogen-dependent cell line
Concentrations 0.1, 1, and 10 μg/ml
Incubation Time 48 h
Method

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In Vivo
In vivo Glycine is the most abundant amino acid in the body and is involved in multiple metabolic pathways. Circulating glycine levels in humans, rats and mice, cats, and dogs range from 0.2-0.4 mM. In rabbits and pigs, they are 1-1.5 mM. Intracellular concentrations are much higher, particularly in renal proximal tubules, which reabsorb filtered glycine and reach 4–10x circulating levels depending on whether they are being actively perfused. Glycine has been reported to lower blood pressure in an NMDA-sensitive fashion[1]. Glycine has an estrogen-like osteoprotective effect in menopause models. It significantly increases the ALP activity, enhances bone mineral density, trabecular number, and connectivity density in OVX mice[2].
Animal Research Animal Models Seven-week-old female Balb/c mice
Dosages 10 mg/kg
Administration orally
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06378346 Recruiting
Prostate Cancer
University of Illinois at Chicago
 May 2024 Phase 2
NCT06242535 Recruiting
Insulin Resistance|Obesity|Cardiovascular Diseases|Cognitive Impairment|Physical Disability|Depression|Inflammation|Hormone Deficiency|Physical Inactivity|Hyperlipidemias|Hypertension|Overeating
Hoskinson Health and Wellness Clinic|Buck Institute for Research on Aging|University of Wyoming
 July 27 2023 Early Phase 1
NCT05799651 Active not recruiting
SARS-CoV-2
Glycovax Pharma Inc.|Government of Canada|JSS Medical Research Inc.|Avance Clinical Pty Ltd.|Seppic
 April 28 2023 Phase 1

Chemical Information & Solubility

Molecular Weight 75.07 Formula

C2H5NO2
CAS No. 56-40-6 SDF Download Glycine SDF
Smiles C(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 15 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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