Glycine

Catalog No.S4821 Batch:S482103

Print

Technical Data

Formula

C2H5NO2
Molecular Weight 75.07 CAS No. 56-40-6
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy.
Targets
MT2 receptor [1] MT1 receptor [1]
9.8(pKi) 9.45(pKi)
In vitro Glycine significantly increases the MG-63 cell proliferation in a dosedependent manner. Activity of alkaline phosphatase (ALP) and phosphorylation of extracellular-signal-regulated kinase are increased by glycine in MG-63 cells. Glycine also increases the BrdU-incorporation and Ki-67 mRNA expression in MCF-7 cells, induces the up-regulation of estrogen receptor-β mRNA expression and estrogen response element-luciferase activity in MG-63 and MCF-7 cells[2].
In vivo Glycine is the most abundant amino acid in the body and is involved in multiple metabolic pathways. Circulating glycine levels in humans, rats and mice, cats, and dogs range from 0.2-0.4 mM. In rabbits and pigs, they are 1-1.5 mM. Intracellular concentrations are much higher, particularly in renal proximal tubules, which reabsorb filtered glycine and reach 4–10x circulating levels depending on whether they are being actively perfused. Glycine has been reported to lower blood pressure in an NMDA-sensitive fashion[1]. Glycine has an estrogen-like osteoprotective effect in menopause models. It significantly increases the ALP activity, enhances bone mineral density, trabecular number, and connectivity density in OVX mice[2].

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    MG-63 osteoblast cell line, MCF-7 estrogen-dependent cell line

  • Concentrations

    0.1, 1, and 10 μg/ml

  • Incubation Time

    48 h

  • Method

    --
Animal Study:

[2]
  • Animal Models

    Seven-week-old female Balb/c mice

  • Dosages

    10 mg/kg

  • Administration

    orally

Selleck's Glycine has been cited by 2 publications

Increased IRF9-STAT2 signaling leads to adaptive resistance toward targeted therapy in melanoma by restraining GSDME-dependent pyroptosis [ J Invest Dermatol, 2022, S0022-202X(22)00096-3] PubMed: 35148998
Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/caspase-1 signaling [ Free Radic Res, 2022, 1-13] PubMed: 35075949

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.