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Garlic oil

Cat.No.E0651

Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.
Garlic oil Chemical Structure

Chemical Structure

Molecular Weight:

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Chemical Information, Storage & Stability

Molecular Weight Formula

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 Storage (From the date of receipt) 2 years -20°C liquid
CAS No. 8000-78-0 -- Storage of Stock Solutions

Solubility

In vitro
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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro

This compound exhibits favorable anti‑cancer potential towards gliomas of various degrees of differentiation. It induces apoptotic death in Human astrocytoma cell lines at a low concentration(0.75 µg/ml-1.5 µg/ml). [2]
In vivo

Garlic oil supplementation during pregnancy and lactation protects against hypertension induced by high-fat (HF) diet in adult male offspring. The beneficial effects of this compound are associated with increased renal mRNA expression and activity of Hydrogen sulfide (H2 S)-generating enzymes, increased NO bioavailability, increased plasma short chain fatty acid levels, and alterations of gut microbiota composition. This supplementation increases abundance of genus Lactobacillus, but decreases genera Turicibacter and Staphylococcus.[3]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00275405 Suspended
Healthy
Albany Medical College
 April 2006 Phase 4

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