Garlic oil

Name: Garlic oil
Brand: Selleck Chemicals
SKU: E0651
Rating: 5 (1 reviews)

Catalog No.E0651 Purity:99%

Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.

Garlic oil Chemical Structure

CAS No. 8000-78-0

Purity & Quality Control

Batch: E065101 Purity: 99%

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Biological Activity

Description	Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.

In vitro
In vitro	Garlic oil exhibits favorable anti‑cancer potential towards gliomas of various degrees of differentiation. Garlic oil induces apoptotic death in Human astrocytoma cell lines at a low concentration(0.75 µg/ml-1.5 µg/ml). ^[2]
Cell Research	Cell lines	Human astrocytoma cell lines
	Concentrations	0.015 µg/ml-150 µg/ml
	Incubation Time	24 h
	Method	Human astrocytoma cell lines are incubated with 15 or 150 µg/ml garlic oil for 24 h, and then used for the MTT assay to determine viability of cells. Annexin V conjugated to fluorescein isothiocyanate (FITC) fluorochrome is used for flow cytometry analysis of cells which are undergoing apoptosis.

In Vivo
In vivo	Garlic oil supplementation during pregnancy and lactation protects against hypertension induced by high-fat (HF) diet in adult male offspring. The beneficial effects of garlic oil are associated with increased renal mRNA expression and activity of Hydrogen sulfide (H2 S)-generating enzymes, increased NO bioavailability, increased plasma short chain fatty acid levels, and alterations of gut microbiota composition. Garlic oil supplementation increases abundance of genus Lactobacillus, but decreases genera Turicibacter and Staphylococcus.^[3]
Animal Research	Animal Models	Pregnant rats
	Dosages	100 mg/kg
	Administration	o.g.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT00275405	Suspended	Healthy	Albany Medical College	April 2006	Phase 4

References

Chemical Information & Solubility

Molecular Weight		Formula	N/A
CAS No.	8000-78-0	SDF	--
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

In vitro
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In vivo
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