Benzoylaconitine

Name: Benzoylaconitine
Brand: Selleck Chemicals
SKU: S0944
Rating: 5 (1 reviews)

Synonyms: Isaconitine, Pikraconitin

Catalog No.S0944 Purity:99.92%

Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.

Benzoylaconitine Chemical Structure

CAS No. 466-24-0

Purity & Quality Control

Batch: S094401 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.92%

99.92

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Biological Activity

Description	Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.

In vitro
In vitro	Benzoylaconitine is a lower toxic monoester type alkaloid considered as the pharmacodynamic constituent in Aconitum species, which exerts an anti-inflammatory effect dependent on MAPK, Akt and nuclear factor-κB (NF-κB) pathways in human synovial cells stimulated with IL-1β.^[1]
Cell Research	Cell lines	IL-1β-stimulated human synovial SW982 cells
	Concentrations	5, 10 µM
	Incubation Time	30 min
	Method	The SW982 cells are pretreated with various doses (0, 5 and 10 μM) of BAC for 30 min, followed by IL-1β stimulation (10 ng/mL) for 12 h. The levels of IL-6 and IL-8 in supernatants of cell cultures are determined by ELISA kits according to the manufacturer's recommendations.

In Vivo
In vivo	Benzoylaconitine shows efficient in vivo anti-inflammatory effect with high ear (69.8 %) and paw (87.1 %) swelling suppressing rate.^[3]

References

Chemical Information & Solubility

Molecular Weight	603.70	Formula	C₃₂H₄₅NO₁₀
CAS No.	466-24-0	SDF	--
Smiles	CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)O)OC)OC)O)COC
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (165.64 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
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