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Allantoin

Synonyms: Glyoxyldiureide, 5-Ureidohydantoin

Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.

Allantoin Chemical Structure

Allantoin Chemical Structure

CAS No. 97-59-6

Purity & Quality Control

Allantoin Related Products

Biological Activity

Description Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.
In Vivo
In vivo The subchronic administration of allantoin (1, 3 or 10 mg/kg, for 7 days) significantly increases the latency time measured during the passive avoidance task in scopolamine-induced cholinergic blockade and normal naïve mice. Allantoin treatment (3 or 10 mg/kg, for 7 days) also increases the expression levels of phosphorylated phosphatidylinositide 3-kinase (PI3K), phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK-3β). Allantoin has memory-enhancing effects, and these effects may be partly mediated by the PI3K-Akt-GSK-3β signal pathway[2].
Animal Research Animal Models adult male Swiss albino mice
Dosages 20, 40, 60 and 80 mg/kg
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06338410 Completed
Kangaroo Mother Care|Oxidative Stress
University of Health Sciences Lahore|Services Hospital Lahore
 August 1 2023 Not Applicable
NCT04325490 Completed
Intertrigo
Mahidol University|HOE pharmaceuticals Sdn. Bhd.
 October 1 2019 Phase 4
NCT04046783 Completed
Cesarean Section; Dehiscence|Scar Keloid|Wound Heal
University of Salerno
 March 2 2019 --
NCT03849677 Completed
Healthy|Diet Modification
Erasme University Hospital|Fonds National de la Recherche Scientifique|Fonds Erasme|Fonds pour la chirurgie cardiaque
 March 10 2019 --
NCT03631394 Completed
Exercise
Loma Linda University
 September 1 2018 Not Applicable

Chemical Information & Solubility

Molecular Weight 158.12 Formula

C4H6N4O3
CAS No. 97-59-6 SDF --
Smiles C1(C(=O)NC(=O)N1)NC(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 7 mg/mL ( (44.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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