Allantoin

Catalog No.S3856 Batch:S385601

Technical Data

Formula	C₄H₆N₄O₃
Molecular Weight	158.12	CAS No.	97-59-6
Solubility (25°C)*	In vitro	DMSO	7 mg/mL (44.27 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.
In vivo	The subchronic administration of allantoin (1, 3 or 10 mg/kg, for 7 days) significantly increases the latency time measured during the passive avoidance task in scopolamine-induced cholinergic blockade and normal naïve mice. Allantoin treatment (3 or 10 mg/kg, for 7 days) also increases the expression levels of phosphorylated phosphatidylinositide 3-kinase (PI3K), phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK-3β). Allantoin has memory-enhancing effects, and these effects may be partly mediated by the PI3K-Akt-GSK-3β signal pathway^[2].

Description

Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.

In vivo

The subchronic administration of allantoin (1, 3 or 10 mg/kg, for 7 days) significantly increases the latency time measured during the passive avoidance task in scopolamine-induced cholinergic blockade and normal naïve mice. Allantoin treatment (3 or 10 mg/kg, for 7 days) also increases the expression levels of phosphorylated phosphatidylinositide 3-kinase (PI3K), phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK-3β). Allantoin has memory-enhancing effects, and these effects may be partly mediated by the PI3K-Akt-GSK-3β signal pathway^[2].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models adult male Swiss albino mice Dosages 20, 40, 60 and 80 mg/kg Administration p.o.

References

Selleck's Allantoin has been cited by 1 publication

尿囊素促进破骨细胞缺陷斑马鱼骨折修复 [ Genetics, 2023, 45(4): 341-353]	PubMed: none

尿囊素促进破骨细胞缺陷斑马鱼骨折修复 [ Genetics, 2023, 45(4): 341-353]

PubMed: none

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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