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Vincamine

Synonyms: Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan

Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.

Vincamine Chemical Structure

Vincamine Chemical Structure

CAS No. 1617-90-9

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Vincamine Related Products

Biological Activity

Description Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.
In vitro
In vitro Vincamine decreases amyloid-β 25-35 induced oxidative stress and reduces reactive oxygen species levels. It significantly reduces the rate of apoptosis in a dose-dependent manner. Vincamine could provide neuroprotection from Aβ25-35 induced PC12 apoptosis through the phosphatidylinositol-3 kinase/Akt signaling pathway[1].
Cell Research Cell lines PC12 cells
Concentrations 20, 40, 80 μM
Incubation Time 3 h
Method

PC12 cells cultured in 6-well plates (4 × 104 cells/well) for 24 h are treated with various concentrations of vincamine for 3 h before the addition of 30 μM Aβ25-35 and further 24 h incubation. Cells are then digested with trypsin and washed twice in phosphate buffered solution (PBS). Thereafter, cells are suspended in 500 μl of PBS and lysed by ultrasonication in the presence of protease inhibitor before centrifugation at 4000 rpm for 5 min. The supernatant is collected for analysis.
In Vivo
In vivo Vincamine could cross the blood-brain barrier, and its antioxidant scavenging capacity to inactivate hydroxyl free radicals is actually ranked in part with Vitamin E[1]. Vincamine decreases the mean arterial blood pressure (by 5-35%), the cardial output and the heart rate. After oral application of 20 mg/kg vincamine in rats, vincamine is rapidly absorbed and eliminated. The apparent elimination half life is 1.71 h. The bioavailability of vincamine after oral administration is 58% suggesting a significant firstpass metabolism. Vincamine is taken up in a high concentration by the different organs, the maximal organ-plasma concentration ratio is 21 for lungs, 14.6 for brain, 14.3 for the kidneys, 8.9 for the liver and 7.6 for the heart. There is no steady-state between plasma and heart, lungs and brain, the elimination from these organs is significantly more rapid than from plasma[2]. Vincamine is mainly metabolized in the liver and excreted by the kidneys and it may also go through cerebral metabolism. In the pharmacokinetic profile of vincamine, the compound is about 64% bound to plasma proteins, and 6% bound to erythrocytes[3].
Animal Research Animal Models male Sprague-Dawley rats
Dosages 10 and 30 mg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 354.44 Formula

C21H26N2O3
CAS No. 1617-90-9 SDF Download Vincamine SDF
Smiles CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(C2)(C(=O)OC)O
Storage (From the date of receipt)

In vitro
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DMSO : 3 mg/mL ( (8.46 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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