Heptamidine Dimethanesulfonate

Synonyms: SBi4211 Dimethanesulfonate

Catalog No.S3389 Purity:99.77%

Heptamidine (SBi4211) Dimethanesulfonate is a novel and potent Pentamidine-related inhibitor of the calcium-binding protein S100B with a Kd of 6.9 μM.

Heptamidine Dimethanesulfonate Chemical Structure

CAS No. 161374-55-6

Purity & Quality Control

Batch: S338901 DMSO]100 mg/mL]false]Water]5 mg/mL]false]Ethanol]Insoluble]false Purity: 99.77%

99.77

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Biological Activity

Description

Heptamidine (SBi4211) Dimethanesulfonate is a novel and potent Pentamidine-related inhibitor of the calcium-binding protein S100B with a Kd of 6.9 μM.

Targets

S100B ^[1]

6.9 μM(Kd)

References
[1] Laura E McKnight, et al. ACS Med Chem Lett . 2012 Dec 13;3(12):975-979.

References

[1] Laura E McKnight, et al. ACS Med Chem Lett . 2012 Dec 13;3(12):975-979.

Chemical Information & Solubility

Molecular Weight	560.68	Formula	C₂₁H₂₈N₄O₂.2CH₄O₃S
CAS No.	161374-55-6	SDF	--
Smiles	C[S](O)(=O)=O.C[S](O)(=O)=O.NC(=N)C1=CC=C(OCCCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (178.35 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 5 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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