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S-Nitrosoglutathione

Synonyms: GSNO , RVC-588 , S-Nitroso-L-glutathione , Nitrosoglutathione

S-nitrosoglutathione (GSNO, RVC-588, S-Nitroso-L-glutathione,Nitrosoglutathione) is an amino acid and nitric oxide donor that, under physiological conditions, spontaneously releases nitric oxide. S-nitrosoglutathione (GSNO) selectively inhibits platelet and NF-κB activation. It induces apoptosis in T cells in low concentrations (< 0.6 mM) while protecting T cells from apoptosis in higher concentrations (1-2 mM).

S-Nitrosoglutathione Chemical Structure

S-Nitrosoglutathione Chemical Structure

CAS No. 57564-91-7

Purity & Quality Control

Batch: E444301 DMSO]67 mg/mL]false]Water]17 mg/mL]false]Ethanol]Insoluble]false Purity: 100.00%
100.00

S-Nitrosoglutathione Related Products

Biological Activity

Description S-nitrosoglutathione (GSNO, RVC-588, S-Nitroso-L-glutathione,Nitrosoglutathione) is an amino acid and nitric oxide donor that, under physiological conditions, spontaneously releases nitric oxide. S-nitrosoglutathione (GSNO) selectively inhibits platelet and NF-κB activation. It induces apoptosis in T cells in low concentrations (< 0.6 mM) while protecting T cells from apoptosis in higher concentrations (1-2 mM).
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04619602 Suspended
Bronchopulmonary Dysplasia
University Hospitals Cleveland Medical Center
 August 1 2024 Phase 1
NCT03926741 Recruiting
Asthma|Healthy Volunteers
James Reynolds|University Hospitals Cleveland Medical Center|Case Western Reserve University|National Heart Lung and Blood Institute (NHLBI)
 April 30 2019 Early Phase 1

Chemical Information & Solubility

Molecular Weight 336.32 Formula

C10H16N4O7S
CAS No. 57564-91-7 SDF Download S-Nitrosoglutathione SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (199.21 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 17 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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