PFI-6

Name: PFI-6
Brand: Selleck Chemicals
SKU: E4657
Rating: 5 (1 reviews)

Catalog No.E4657 Purity:99.08%

PFI-6 is a selective MLLT1/3 probe that targets the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 demonstrates increased affinity and selectivity for MLLT1/3 than other human YEATS domain proteins (YEATS2/4).

PFI-6 Chemical Structure

CAS No. 2675452-91-0

Purity & Quality Control

Batch: E465701 DMSO]78 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.08%

99.08

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	PFI-6 is a selective MLLT1/3 probe that targets the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 demonstrates increased affinity and selectivity for MLLT1/3 than other human YEATS domain proteins (YEATS2/4).

References

[1] Raux B, et al. Bioorg Med Chem Lett. 2024 Jan 15:98:129546.

Chemical Information & Solubility

Molecular Weight	391.42	Formula	C₂₂H₂₁N₃O₄
CAS No.	2675452-91-0	SDF	Download PFI-6 SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 78 mg/mL ( (199.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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