N-Methylnicotinamide

Name: N-Methylnicotinamide
Brand: Selleck Chemicals
SKU: S3321
Rating: 5 (1 reviews)

Synonyms: MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide

Catalog No.S3321 Purity:98.29%

N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.

N-Methylnicotinamide Chemical Structure

CAS No. 114-33-0

Purity & Quality Control

Batch: S332101 DMSO]27 mg/mL]false]Water]27 mg/mL]false]Ethanol]27 mg/mL]false Purity: 98.29%

98.29

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Biological Activity

Description	N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06150950	Recruiting	Heart Failure Congenital\|Single-ventricle	Stanford University\|Vanderbilt University Medical Center\|Adult Congenital Heart Association\|Julie Fletcher Memorial Fund\|Pete Huttlinger Memorial Fund	May 5 2024	Not Applicable
NCT06264895	Active not recruiting	Social Exclusion\|Chronic Disease\|Physical Disability\|Addiction	University of Dublin Trinity College	February 26 2024	Not Applicable

References

[1] Nan Jiang, et al. Mol Nutr Food Res. 2016 Jul;60(7):1625-36.

Chemical Information & Solubility

Molecular Weight	136.15	Formula	C₇H₈N₂O
CAS No.	114-33-0	SDF	--
Smiles	CNC(=O)C1=CC=CN=C1
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 27 mg/mL ( (198.31 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 27 mg/mL

Ethanol : 27 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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