Larazotide

Name: Larazotide
Brand: Selleck Chemicals
SKU: E2035
Rating: 5 (1 reviews)

Synonyms: AT-1001

Catalog No.E2035 Purity:98.82%

Larazotide(AT-1001) is an antagonist of Zonulin, which appears safe and well-tolerated and may offer potential benefit as an adjuvant to immune-targeted therapies.

Larazotide Chemical Structure

CAS No. 258818-34-7

Purity & Quality Control

Batch: Purity: 98.82%

98.82

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	Larazotide(AT-1001) is an antagonist of Zonulin, which appears safe and well-tolerated and may offer potential benefit as an adjuvant to immune-targeted therapies.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT01396213	Completed	Celiac Disease	9 Meters Biopharma Inc.\|Teva Pharmaceuticals USA	November 7 2011	Phase 2
NCT00620451	Completed	Celiac Disease	9 Meters Biopharma Inc.	February 2008	Phase 2
NCT00362856	Completed	Celiac Disease	9 Meters Biopharma Inc.	September 13 2006	Phase 2
NCT00386490	Completed	Healthy	9 Meters Biopharma Inc.	January 10 2006	Phase 1
NCT00386165	Completed	Celiac Disease	9 Meters Biopharma Inc.	November 29 2005	Phase 1

References

[1] Yonker LM, et al. Crit Care Explor. 2022 Feb 18;10(2):e0641.

Chemical Information & Solubility

Molecular Weight	725.83	Formula	C₃₂H₅₅N₉O₁₀
CAS No.	258818-34-7	SDF	--
Smiles	CC(C)CC(NC(=O)C(NC(=O)CNC(=O)CN)C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NCC(O)=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 25 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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