Isosorbide

Synonyms: D-Isosorbide,Dianhydro-D-glucitol

Isosorbide(D-Isosorbide,Dianhydro-D-glucitol) is a heterocyclic compound that is derived from glucose, used as a diuretic.

Isosorbide Chemical Structure

Isosorbide Chemical Structure

CAS No. 652-67-5

Purity & Quality Control

Isosorbide Related Products

Biological Activity

Description Isosorbide(D-Isosorbide,Dianhydro-D-glucitol) is a heterocyclic compound that is derived from glucose, used as a diuretic.
In vitro
In vitro

Isosorbide increases urine volume by increasing the amount of osmotically active solute in the urine. Osmotic diuretics also increase the osmolarity of plasma. Isosorbide is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased. [1]

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NCT05954689 Not yet recruiting
Tourniquets|Anesthesia Conduction|Anesthetics Local|Hypertension
Hospital da Luz Portugal
July 10 2023 Not Applicable
NCT05341856 Unknown status
Recurrent Pregnancy Loss
Al-Azhar University
May 1 2022 Early Phase 1
NCT04297241 Completed
Fontan
Children''s Hospital Medical Center Cincinnati
December 12 2019 Phase 2
NCT02053493 Completed
Heart Failure
Adrian Hernandez|National Heart Lung and Blood Institute (NHLBI)|Mayo Clinic|University of Vermont|Duke University
April 2014 Phase 2
NCT02712125 Completed
Isolated (Idiopathic) Oligohydramnios
Benha University
August 2013 Phase 2|Phase 3
NCT00930618 Completed
Prolonged Pregnancy|Nulliparity
Assistance Publique - Hôpitaux de Paris
June 2009 Phase 3

Chemical Information & Solubility

Molecular Weight 146.14 Formula

C6H10O4

CAS No. 652-67-5 SDF Download Isosorbide SDF
Smiles C1C(C2C(O1)C(CO2)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 29 mg/mL ( (198.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 29 mg/mL

Ethanol : 29 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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