IMP-1088

Name: IMP-1088
Brand: Selleck Chemicals
SKU: E0428
Rating: 5 (1 reviews)

Catalog No.E0428 Purity:98.16%

IMP-1088 is a potent dual inhibitor of human N-myristoyltransferases NMT1 and NMT2, with an IC50 of <1 nM for HsNMT1 and HsNMT2 and a Kd of <210 pM for HsNMT1. It effectively inhibits the production of infectious rhinovirus virions by blocking the N-myristoylation of the rhinovirus VP0 protein.

IMP-1088 Chemical Structure

CAS No. 2059148-82-0

Purity & Quality Control

Batch: E042801 DMSO]91 mg/mL]false]Ethanol]30 mg/mL]false]Water]Insoluble]false Purity: 98.16%

98.16

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Biological Activity

Description	IMP-1088 is a potent dual inhibitor of human N-myristoyltransferases NMT1 and NMT2, with an IC50 of <1 nM for HsNMT1 and HsNMT2 and a Kd of <210 pM for HsNMT1. It effectively inhibits the production of infectious rhinovirus virions by blocking the N-myristoylation of the rhinovirus VP0 protein.

References

[1] Mousnier A, et al. Nat Chem. 2018 Jun;10(6):599-606.

Chemical Information & Solubility

Molecular Weight	453.53	Formula	C₂₅H₂₉F₂N₅O
CAS No.	2059148-82-0	SDF	Download IMP-1088 SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 91 mg/mL ( (200.64 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 30 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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