Hypromellose

Name: Hypromellose
Brand: Selleck Chemicals
SKU: S4444
Rating: 5 (1 reviews)

Synonyms: Hydroxypropyl Methyl Cellulose, HPMC, Celacol HPM 5000, Hydroxypropylmethyl cellulose

Catalog No.S4444 Purity:99%

Hypromellose (Hydroxypropyl Methyl Cellulose, HPMC, Celacol HPM 5000) is a commonly employed cellulose ether used in the fabrication of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect.

Hypromellose Chemical Structure

CAS No. 9004-65-3

Purity & Quality Control

Batch: S444401 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]Insoluble]false Purity: 99%

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	Hypromellose (Hydroxypropyl Methyl Cellulose, HPMC, Celacol HPM 5000) is a commonly employed cellulose ether used in the fabrication of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05825599	Completed	Dry Eye\|Dry Eye Disease\|Kerato Conjunctivitis Sicca	C.O.C. Farmaceutici S.r.l.	September 6 2022	Not Applicable
NCT01964131	Completed	Gastric Ulcer\|Duodenal Ulcer\|Anastomotic Ulcer\|Reflux Esophagitis\|Etc.	AstraZeneca	October 2013	Phase 1
NCT01340833	Completed	Cancer	GlaxoSmithKline	June 8 2011	Phase 1

References

[1] Chi L Li, et al. J Pharm Pharmacol. 2005 May;57(5):533-46.

Chemical Information & Solubility

Molecular Weight		Formula
CAS No.	9004-65-3	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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