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Guaiazulene

Synonyms: Azulon, Vetivazulen

Guaiazulene (Azulon, Vetivazulen) is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil, which also serve as its commercial sources.

Guaiazulene Chemical Structure

Guaiazulene Chemical Structure

CAS No. 489-84-9

Purity & Quality Control

Batch: S399501 DMSO]39 mg/mL]false]]]false]]]false Purity: 99.95%
99.95

Guaiazulene Related Products

Biological Activity

Description Guaiazulene (Azulon, Vetivazulen) is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil, which also serve as its commercial sources.
In vitro
In vitro Guaiazulene has in vitro cytotoxic activity against neuron and N2a-NB cells[1].
Cell Research Cell lines N2a-NB cells
Concentrations 10, 25, 50, 75, 100, 150, 200 and 400 mg/L
Incubation Time 24 h
Method

The cells were seeded in 96-well plastic plates at a density of 1×104 cells/well and incubated in a humidified atmosphere of 5% CO2 at 37°C for 24 h. Cell viability assay was performed using the MTT cell proliferation kit. Pure water was added in the control group. At the end of the experiment, the neurons, and N2a-NB cells were incubated with 20 µL of MTT for 30 min at 37°C. After washing the blue formazan was extracted from cells with isopropanol/formic acid (955)and was photometrically determined at 570 nm.

Chemical Information & Solubility

Molecular Weight 198.30 Formula

C15H18
CAS No. 489-84-9 SDF --
Smiles CC1=C2C=CC(=C2C=C(C=C1)C(C)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (196.67 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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