Ethacrynic Acid

Name: Ethacrynic Acid
Brand: Selleck Chemicals
SKU: S5561
Rating: 5 (2 reviews)

Catalog No.S5561 Purity:99.9%

Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.

Ethacrynic Acid Chemical Structure

CAS No. 58-54-8

Purity & Quality Control

Batch: S556101 DMSO]61 mg/mL]false]]]false]]]false Purity: 99.9%

99.9

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Biological Activity

Description	Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT02852564	Completed	Bladder Cancer	Eugene Lee MD\|University of Kansas Medical Center	August 2016	Phase 1

Chemical Information & Solubility

Molecular Weight	303.14	Formula	C₁₃H₁₂Cl₂O₄
CAS No.	58-54-8	SDF	--
Smiles	CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 61 mg/mL ( (201.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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