D-Phenylalanine

Name: D-Phenylalanine
Brand: Selleck Chemicals
SKU: S4153
Rating: 5 (1 reviews)

Catalog No.S4153 Purity:99.9%

D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain.

D-Phenylalanine Chemical Structure

CAS No. 673-06-3

Purity & Quality Control

Batch: S415301 Water]1 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.9%

99.9

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Biological Activity

Description

D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain.

Targets

carboxypeptidase A ^[1]

endorphinase ^[1]

enkephalinase ^[1]

In vitro
In vitro	The binding of D-Phenylalanine to carboxypeptidase A confers anion sensitivity upon the function of the enzyme by breaking the hydrogen bond between the active site base, Glu-270, and the zinc-bound water molecule. ^[1]

In Vivo
In vivo	D-Phenylalanine (500 mg/kg p.o.) produces a small increase in aversive threshold which is not statistically significant and not naloxone reversible. Acetylsalicylic acid (200 mg/kg p.o.) but not zomepirac sodium (200 mg/kg p.o.) in combination with D-phenylalanine (500 mg/kg) produces a small statistically significant increase in aversive threshold. ^[2]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05514470	Not yet recruiting	Interstitial Lung and Liver Disease\|Infantile Liver Failure Syndrome 1\|Neurologic Endocrine and Pancreatic Disease Multisystem Infantile-Onset 2\|Rajab Interstitial Lung Disease With Brain Calcifications 2	Assistance Publique - Hôpitaux de Paris	April 2024	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	165.19	Formula	C₉H₁₁NO₂
CAS No.	673-06-3	SDF	Download D-Phenylalanine SDF
Smiles	C1=CC=C(C=C1)CC(C(=O)O)N
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 1 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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