Clopamide

Name: Clopamide
Brand: Selleck Chemicals
SKU: S4316
Rating: 5 (1 reviews)

Catalog No.S4316 Purity:99.68%

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do.

Clopamide Chemical Structure

CAS No. 636-54-4

Purity & Quality Control

Batch: Purity: 99.68%

99.68

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Biological Activity

Description	Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do.

In vitro
In vitro	Clopamide exhibits no inhibition of LDL peroxidation induces either by copper ions or by cultured endothelial cells. ^[1] Clopamide results in True Tubular Excretion Fraction (TTEF) in renal tubular cells. ^[2]

In Vivo
In vivo	Clopamide (40 mg, orally) combined with Chloramphenicol (1 g, orally) and Ethacrynic acid (150 mg, orally) increases the urinary excretion of chloramphenicol and its metabolites (aryl amines and total nitro compounds) in vivo. ^[3]

References

Chemical Information & Solubility

Molecular Weight	345.84	Formula	C₁₄H₂₀ClN₃O₃S
CAS No.	636-54-4	SDF	Download Clopamide SDF
Smiles	CC1CCCC(N1NC(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 69 mg/mL ( (199.51 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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