(-)-Catechin gallate

Name: (-)-Catechin gallate
Brand: Selleck Chemicals
SKU: E0239
Rating: 5 (1 reviews)

Synonyms: (-)-CG

Catalog No.E0239 Purity:99.81%

(-)-Catechin gallate ((-)-CG) is a catechin polyphenol that has been found in green tea extracts with diverse biological activities.

(-)-Catechin gallate Chemical Structure

CAS No. 130405-40-2

Purity & Quality Control

Batch: E023901 DMSO]88 mg/mL]false]]]false]]]false Purity: 99.81%

99.81

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Biological Activity

Description	(-)-Catechin gallate ((-)-CG) is a catechin polyphenol that has been found in green tea extracts with diverse biological activities.

In vitro
In vitro	(-)-Catechin gallate is a minor polyphenolic constituent in green tea, which induces apoptosis of cells derived from tissues of the human oral cavity by the more specific TUNEL procedure.^[1]
Cell Research	Cell lines	Immortalized epithelioid gingival S-G cells, salivary gland squamous carcinoma HSG cells, normal gingival HGF-1 fibroblasts, tongue squamous carcinoma CAL27 cells
	Concentrations	50, 100, 150, 200 µM
	Incubation Time	3 days
	Method	Individual wells of a 96-well microtiter tissue culture plate are inoculated with 0.2 ml of the growth medium containing 2×10<sup>4</sup>cells/well for a 1-day exposure, 1.5×10<sup>4</sup>cells/ well for a 2-day exposure and 1×10<sup>4</sup>cells/well for a 3-day exposure to the test agents. After 1 day of incubation, the growth medium is removed and replaced with exposure medium, with or without varied concentrations of the test agents. In some studies the cells are coexposed to CG and 100 Units/ml catalase. After 1-3 days of exposure to the test agents, viability is assessed with the neutral red (NR) assay.

References

[1] Babich H, et al. Toxicol Lett. 2007 Jul 10;171(3):171-80.

Chemical Information & Solubility

Molecular Weight	442.37	Formula	C₂₂H₁₈O₁₀
CAS No.	130405-40-2	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 88 mg/mL ( (198.92 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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