BMS-911172

Name: BMS-911172
Brand: Selleck Chemicals
SKU: E1628
Rating: 5 (1 reviews)

Catalog No.E1628 Purity:99.39%

BMS-911172 is a brain penetrant, selective inhibitor of adaptor protein 2-associated kinase 1 (AAK1) with an IC50 value of 12 nM. BMS-911172 inhibits μ2 phosphorylation and has potential as a therapeutic agent in neuropathic pain research.

BMS-911172 Chemical Structure

CAS No. 1644248-18-9

Purity & Quality Control

Batch: E162801 DMSO]68 mg/mL]false]Ethanol]68 mg/mL]false]Water]Insoluble]false Purity: 99.39%

99.39

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Biological Activity

Description	BMS-911172 is a brain penetrant, selective inhibitor of adaptor protein 2-associated kinase 1 (AAK1) with an IC50 value of 12 nM. BMS-911172 inhibits μ2 phosphorylation and has potential as a therapeutic agent in neuropathic pain research.

References

[1] Hartz RA, et al. J Med Chem. 2021 Aug 12;64(15):11090-11128.

Chemical Information & Solubility

Molecular Weight	339.34	Formula	C₁₆H₁₉F₂N₃O₃
CAS No.	1644248-18-9	SDF	Download BMS-911172 SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 68 mg/mL ( (200.38 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 68 mg/mL

Water : Insoluble

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In vivo
Batch:

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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