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Bilibubin

Synonyms: Bilirubin

Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.

Bilibubin Chemical Structure

Bilibubin Chemical Structure

CAS No. 635-65-4

Purity & Quality Control

Batch: S511601 DMSO]3 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

Bilibubin Related Products

Biological Activity

Description Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.
In vitro
In vitro As a potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM‐1) or intercellular adhesion molecule 1 (ICAM-1)[1].
Cell Research Cell lines Human umbilical vein endothelial cells (HUVECs)
Concentrations 20 μmol/L
Incubation Time 24 h
Method HUVEC monolayers are incubated with TNF-α (5 ng/mL) in the presence of bilirubin (BR; 20 μmol/L) or the bilirubin vehicle (Veh) for 24 hours, and protein levels of IL‐6, IL‐8, IL‐1β, MCP‐1, M‐CSF, and RANTES in cell-culture medium are determined.

Chemical Information & Solubility

Molecular Weight 584.66 Formula

C33H36N4O6
CAS No. 635-65-4 SDF Download Bilibubin SDF
Smiles CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)C=C3C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)C=C4C(=C(C(=O)N4)C=C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 3 mg/mL ( (5.13 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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