Bendamustine

Name: Bendamustine
Brand: Selleck Chemicals
SKU: S5939
Rating: 5 (14 reviews)

Synonyms: SDX105

Catalog No.S5939 Purity:99.51%

Bendamustine is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.

Bendamustine Chemical Structure

CAS No. 16506-27-7

Purity & Quality Control

Batch: S593901 DMSO]72 mg/mL]false]Ethanol]7 mg/mL]false]Water]Insoluble]false Purity: 99.51%

99.51

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Biological Activity

Description	Bendamustine is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05551936	Recruiting	Follicular Lymphoma	Vaishalee Kenkre\|Epizyme Inc.\|University of Wisconsin Madison\|Big Ten Cancer Research Consortium	January 26 2023	Phase 1\|Phase 2
NCT05023980	Active not recruiting	Chronic Lymphocytic Leukemia\|Small Lymphocytic Lymphoma	Loxo Oncology Inc.\|Eli Lilly and Company	September 23 2021	Phase 3

Chemical Information & Solubility

Molecular Weight	358.26	Formula	C₁₆H₂₁Cl₂N₃O₂
CAS No.	16506-27-7	SDF	--
Smiles	CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 72 mg/mL ( (200.97 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 7 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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