3-Hydroxybutyric acid (BHB)

Name: 3-Hydroxybutyric acid (BHB)
Brand: Selleck Chemicals
SKU: S1031
Rating: 5 (1 reviews)

Synonyms: 3-hydroxybutanoic acid, β-Hydroxybutyric acid

Catalog No.S1031 Purity:99.94%

3-Hydroxybutyric acid (BHB) is a small molecule metabolite that is elevated in type I diabetes.,

3-Hydroxybutyric acid (BHB) Chemical Structure

CAS No. 300-85-6

Purity & Quality Control

Batch: Purity: 99.94%

99.94

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Biological Activity

Description	3-Hydroxybutyric acid (BHB) is a small molecule metabolite that is elevated in type I diabetes.,

In vitro
In vitro	3-Hydroxybutyric acid (BHB) suppresses activation of the NLRP3 inflammasome in response to several structurally unrelated NLRP3 activators, without impacting NLRC4, AIM2 or non-canonical caspase-11 inflammasome activation. 3-Hydroxybutyric acid reduces the NLRP3 inflammasome mediated IL-1β and IL-18 production in human monocytes.^[1]
Cell Research	Cell lines	Mouse bone marrow derived macrophages (BMDMs)
	Concentrations	10 mM
	Incubation Time	1 h
	Method	BMDMs are primed with LPS for 4 hours and stimulated with ATP for 1 hour in the presence of various concentrations of 3-Hydroxybutyric acid. Western blot analyses caspase-1 (active subunit p20) and IL-1β (active p17) in the supernatant of BMDMs

In Vivo
In vivo	Exogenous 3‐HB effectively delayed tumor growth in A549 xenograft mice.

References

Chemical Information & Solubility

Molecular Weight	104.10	Formula	C₄H₈O₃
CAS No.	300-85-6	SDF	--
Density	1.126 g/mL at 25 °C
Storage (From the date of receipt)	2 years -20°C(in the dark) liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C(in the dark) liquid		1 month-20°Cin solvent

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