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DNA/RNA Synthesis

Isoform-selective Products

tRNA synthetase RdRp DNA synthesis helicase ribonucleotide reductase

Signaling Pathway

DNA/RNA Synthesis Products

All (163)
DNA/RNA Synthesis Inhibitors (133)
DNA/RNA Synthesis Activators (4)
DNA/RNA Synthesis Antagonist (1)
DNA/RNA Synthesis Modulators (4)
New DNA/RNA Synthesis Products

Catalog No.	Product Name	Information	Product Use Citations
S1166	Cisplatin	Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Nat Cancer, 2024, 10.1038/s43018-024-00814-0 Nat Commun, 2024, 15(1):5775 Nat Commun, 2024, 15(1):2853
S7418	Cycloheximide	Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Signal Transduct Target Ther, 2024, 9(1):65 Mol Cancer, 2024, 23(1):143 Cell Metab, 2024, 36(7):1598-1618.e11
S1714	Gemcitabine	Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Drug Resist Updat, 2024, 74:101079 Nat Commun, 2024, 15(1):1287
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1224	Oxaliplatin	Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Mol Cancer, 2024, 23(1):186 Mol Cancer, 2024, 23(1):23 Gastroenterology, 2024, S0016-5085(24)00062-3
S1237	TMZ(Temozolomide)	TMZ(Temozolomide) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.	Cell Discov, 2024, 10(1):39 Cell Death Dis, 2024, 15(3):205 NPJ Precis Oncol, 2024, 8(1):59
S1491	Fludarabine	Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.	Nat Commun, 2024, 15(1):1718 Cell Rep Med, 2024, 5(2):101420 Cell Death Dis, 2024, 15(8):600
S1149	Gemcitabine HCl	Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.	Int J Biol Sci, 2024, 20(4):1389-1409 Phytomedicine, 2024, 155377 Cell Oncol (Dordr), 2024, 10.1007/s13402-024-00939-5
S1215	Carboplatin	Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Commun, 2024, 15(1):1158 Cell Rep Med, 2024, S2666-3791(24)00201-5
S1214	Bleomycin sulfate	Bleomycin sulfate is a glycopeptide antibiotic and a DNA synthesis inhibitor, as well as an anticancer agent for squamous cell carcinomas (SCC) with an IC50 of 4 nM in UT-SCC-19A cells. Bleomycin sulfate is a DNA synthesis inhibitor.	Bioact Mater, 2024, 32:488-501 Nat Commun, 2024, 15(1):1429 EMBO J, 2024, 43(1):61-86
S8146	Mitomycin C	Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Nucleic Acids Res, 2024, gkae740 Clin Transl Med, 2024, 14(2):e1586 J Neuroinflammation, 2024, 21(1):136
S1117	Triciribine (API-2)	Triciribine (API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.	J Cell Sci, 2023, 136(4)jcs259788 Exp Gerontol, 2023, 173:112091 EJHaem, 2023, 4(3):631-638
S8932	Remdesivir (GS-5734)	Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Antiviral Res, 2024, 225:105840 Int J Mol Sci, 2024, 25(3)1427 Int J Mol Sci, 2024, 24;25(3):1427.
S1648	Cytarabine	Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.	Nat Commun, 2024, 15(1):4739 Blood Adv, 2024, 8(20):5315-5329 iScience, 2024, 27(1):108667
S3035	Daunorubicin HCl	Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with K_i of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.	Nat Commun, 2024, 15(1):4739 Haematologica, 2024, 109(6):1713-1725 Int J Oncol, 2024, 64(6)66
S2684	Pidnarulex (CX-5461)	Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.	Mol Cell, 2024, 84(8):1527-1540.e7 Cell Rep Med, 2024, 5(10):101778 Sci Rep, 2024, 14(1):4060
S1229	Fludarabine Phosphate	Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.	J Autoimmun, 2024, 149:103307 Cell Death Dis, 2024, 15(3):224 J Biomed Sci, 2022, 29(1):20
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375 Cancer Cell, 2022, 40(10):1128-1144.e8
S1896	Hydroxyurea	Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.	Nat Commun, 2024, 15(1):7360 iScience, 2024, 27(4):109580 Sci Adv, 2024, 10(21):eadk8908
S2794	Sofosbuvir	Sofosbuvir is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.	J Med Virol, 2024, 96(7):e29787 PLoS One, 2024, 19(5):e0303265 mBio, 2023, 10.1128/mbio.01318-23
S1212	Bendamustine HCl	Bendamustine HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.	Res Sq, 2024, rs.3.rs-3848777 Cell Death Discov, 2023, 9(1):39 Front Immunol, 2022, 13:1045710
S7742	SCR7	SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). It increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos.	iScience, 2024, 27(2):108814 Nat Commun, 2023, 14(1):4761 Nat Commun, 2023, 14(1):4761
S2239	Tubacin	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Dev Cell, 2024, S1534-5807(24)00326-5 Br J Cancer, 2023, 10.1038/s41416-023-02195-0 Int J Mol Sci, 2023, 24(5)4720
S1156	Capecitabine	Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.	Genes Dis, 2024, 11(1):430-448 Naunyn Schmiedebergs Arch Pharmacol, 2024, 10.1007/s00210-024-03145-0 J Pers Med, 2022, 12(2)258
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Cell Rep Med, 2024, 5(7):101615 Mol Cancer Res, 2024, 22(1):82-93
S1373	Daptomycin	Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.	Molecules, 2023, 28(2)621 Infect Drug Resist, 2023, 16:4867-4879 Infect Drug Resist, 2023, 16:4867-4879
S1199	Cladribine	Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.	Oncotarget, 2024, 15:220-231 Exp Hematol Oncol, 2023, 12(1):23 Neurol Neuroimmunol Neuroinflamm, 2023, 10(5)e200149
S7419	Blasticidin S HCl	Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation. It is used to select transfected cells carrying bsr or BSD resistance genes.	Nucleic Acids Res, 2024, gkae787 Cell Rep Med, 2024, 5(5):101533 Pharmacol Res, 2024, 206:107283
S5582	Cytarabine hydrochloride	Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.	Blood, 2022, blood.2022016090 Clin Transl Med, 2022, 12(2):e722 Front Pharmacol, 2022, 13:1032975
S7975	Favipiravir (T-705)	Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.	J Med Virol, 2024, 96(1):e29372 Okayama University, 2023 , 10.18926/65391 Nat Commun, 2022, 13(1):2256
S3190	m6A (N6-methyladenosine)	m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.	Biosci Rep, 2024, 44(1)BSR20231430 Nucleic Acids Res, 2023, 51(2):517-535 Oncol Rep, 2023, 49(5)94
S1218	Clofarabine	Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.	Front Oncol, 2023, 13:1287444 Cancer Res, 2022, 82(4):721-733 Clin Transl Med, 2022, 12(2):e747
S8246	RK-33	RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.	Cell Rep, 2024, 43(3):113937 JCI Insight, 2023, 8(7)e167566 Mol Immunol, 2023, 154:54-60
S1840	Lomustine	Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.	Sci Rep, 2024, 14(1):4303 Cell Rep Med, 2023, S2666-3791(23)00156-8 Mol Biol Cell, 2023, 34(5):ar47
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Res, 2023, 83(16):2750-2762 Comput Struct Biotechnol J, 2023, 21:3827-3840 Comput Struct Biotechnol J, 2023, 21:3827-3840
S1807	Acyclovir (Aciclovir)	Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.	Cell, 2023, 186(14):3033-3048.e20 iScience, 2022, 25(12):105682 Pharmaceutics, 2022, 14(3)536
S1289	Carmofur	Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.	JCI Insight, 2023, 8(9)e166850 Cell Death Discov, 2023, 9(1):451 Int J Mol Sci, 2023, 24(7)6062
S7470	Triapine (3-AP)	Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.	J Virol, 2023, 97(8):e0026723 Res Sq, 2023, rs.3.rs-3126261 Cancer Res, 2022, 82(4):721-733
S1192	Raltitrexed	Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	Mol Ther, 2022, S1525-0016(22)00717-1 ACS Chem Neurosci, 2022, 13(17):2646-2657 Biochem Biophys Res Commun, 2022, 610:1-7
S1221	Dacarbazine	Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.	Cell Death Dis, 2023, 14(6):348 BMC Complement Med Ther, 2023, 23(1):111 BMC Complement Med Ther, 2023, 23(1):111
S1305	Mercaptopurine (6-MP)	Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.	Nat Commun, 2023, 14(1):5913 Nat Commun, 2023, 14(1):5913 J Pers Med, 2022, 12(2)258
S8434	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).	iScience, 2024, 27(2):108814 Cell Prolif, 2023, 56(4):e13384 Cancer Med, 2023, 12(6):6594-6602
S7718	BMH-21	BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.	Nucleic Acids Res, 2024, gkae316 Elife, 2024, 13e80684 J Biol Chem, 2024, 300(3):107115
S1213	Nelarabine	Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.	Cancer Res, 2022, 82(4):721-733 Cell Rep, 2022, 39(10):110913 J Pers Med, 2022, 12(2)258
S7679	YK-4-279	YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).	Nat Commun, 2024, 15(1):4590 Cancers -Basel), 2023, 15(19)4772 Cell Chem Biol, 2022, 29(8):1325-1332.e4
S1764	Rifampin (Rifampicin)	Rifampin (Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.	Cell Death Dis, 2023, 14(1):64 Int J Mol Sci, 2022, 23(13)7383 Biomedicines, 2021, 9(8)996
S1299	Floxuridine (FUDR)	Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Cell Chem Biol, 2021, S2451-9456(21)00306-8
S7918	BrdU (Bromodeoxyuridine)	BrdU (Bromodeoxyuridine) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.	CNS Neurosci Ther, 2024, 30(6):e14800 Heliyon, 2024, 10(3):e24779 Int J Ophthalmol, 2024, 17(6):1018-1027
S1949	Menadione (Vitamin K3)	Menadione (Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Med -N Y, 2022, S2666-6340-2200365-8 Mol Cell, 2021, S1097-2765(21)00269-0 DNA Repair (Amst), 2021, 105:103152
S1995	Procarbazine HCl	Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S4239	Bergapten	Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00579-z
S4288	Chloroambucil	Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.	bioRxiv, 2023, 2023.01.17.524444 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S1516	Cidofovir	Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.	Oncol Lett, 2021, 21(4):280 Nat Biotechnol, 2019, 37(3):303-313 Antiviral Res, 2019, 162:178-185
S2678	NSC 207895	NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.	PLoS One, 2024, 19(1):e0295629 Front Oncol, 2021, 11:582511 Genes Dev, 2020, 34(7-8):526-543
S1778	Trifluridine (NSC 75520)	Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.	Nat Med, 2023, 29(3):605-614 JCI Insight, 2022, 7(22e158060) Biochem Biophys Res Commun, 2022, 610:119-126
S1300	Tegafur (FT-207)	Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S4194	Azaguanine-8	Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00579-z
S8144	Halofuginone	Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.	Cell Rep, 2024, 43(9):114728 J Neurochem, 2024, 10.1111/jnc.16102 Infect Agent Cancer, 2023, 18(1):27
S1983	Adenine HCl	Adenine HCl(6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S4227	Fidaxomicin	Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.	J Antimicrob Chemother, 2024, dkae101 Nucleic Acids Res, 2023, 51(19):e99 bioRxiv, 2023, 2023.03.13.532464
S1384	Mizoribine	Mizoribine is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.	EMBO J, 2023, e110620. bioRxiv, 2022, 2021.07.02.450964 Cell Death Differ, 2021, 10.1038/s41418-021-00853-5
S4297	Mupirocin	Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.	Infect Drug Resist, 2023, 16:4867-4879 Infect Drug Resist, 2023, 16:4867-4879 Anaerobe, 2020, 62:102169
S1217	Cyclophosphamide	Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.	J Immunother, 2024, 10.1097/CJI.0000000000000505 Oncol Lett, 2024, 27(4):158 Stem Cell Res Ther, 2023, 14(1):75
S1973	Cyclocytidine HCl	Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.	Transl Oncol, 2023, 35:101712 PeerJ, 2022, 10:e13719 Acta Biochim Biophys Sin (Shanghai), 2020, 14 pii: gmaa017
S4803	Thymidine	Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix.	Nat Commun, 2024, 15(1):2371 EBioMedicine, 2024, 103:105129 Sci Adv, 2024, 10(21):eadk8908
S2029	Uridine	Uridine (NSC 20256,β-Uridine, Uridin) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.	Cancer Res, 2022, canres.1707.2021 iScience, 2022, 25(5):104293 J Med Chem, 2021, 64(18):13918-13932
S5948	Amodiaquine	Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.	Molecules, 2024, 29(6)1363 Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9 bioRxiv, 2020, 10.1101/2020.04.13.039917
S1907	Metronidazole	Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.	Microorganisms, 2022, 10(7)1421 Elife, 2021, 10e69795 Bone Joint Res, 2020, 16;9(4):152-161
S1760	Rifapentine	Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.	Int J Mol Sci, 2022, 23(13)7383 Front Microbiol, 2020, 10:2936 mSphere, 2018, 3(5)
S1784	Vidarabine	Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.	Neuron, 2017, 96(6):1290-1302 ACS Appl Mater Interfaces, 2016, 8(39):25818-25824 Biogerontology, 2016, 17(5-6):907-920
S1826	Nedaplatin	Nedaplatin(NSC 375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Nat Commun, 2019, 10(1):5654 Cancer Res, 2018, 78(19):5694-5705 Oncol Lett, 2016, 12(5):4195-4202
S7445	APX-3330	APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.	J Transl Med, 2023, 21(1):183 Cell Death Dis, 2022, 13(2):124 Cancer Research on Prevention and Treatment, 2020, (7): 492-497
S1334	Flupirtine maleate	Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.	Assay Drug Dev Technol, 2019, 17(7):310-321 Elife, 2015, 4
S7757	6-Thio-dG	6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.	Cell Death Discov, 2024, 10(1):381 Radiation Medicine and Protection, 2022, 64-71 Clin Sci (Lond), 2020, 10.1042/CS20190890
S9521	Pentostatin	Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.	Res Sq, 2023, rs.3.rs-2276903 Nat Metab, 2020, 10.1038/s42255-020-0227-4
S8539	TAS-102	TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.	STAR Protoc, 2024, 5(2):103090 J Exp Clin Cancer Res, 2023, 42(1):8 Adv Sci (Weinh), 2021, e2103360
S3669	Carmustine	Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Cancer Res, 2021, 81(23):6044-6057
S8850	JH-RE-06	JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).	Nucleic Acids Res, 2024, gkae317 Nucleic Acids Res, 2024, gkae785 Cell Rep, 2024, 43(5):114205
S7546	Pritelivir (BAY 57-1293)	Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.	PLoS Pathog, 2021, 17(11):e1010117 J Virol, 2021, JVI0166621
S9718	TK216	TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.	J Biol Chem, 2024, 300(6):107375 Sci Rep, 2023, 13(1):14360 Sci Rep, 2023, 13(1):14360
S1790	Rifaximin	Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.	Int J Mol Sci, 2022, 23(13)7383
S5552	Amenamevir	Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.	J Biomol Struct Dyn, 2020, 1-14
S0280	Madrasin	Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.	Leukemia, 2023, 37(8):1649-1659
S8095	Tubercidin	Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.	Mol Cell, 2020, 80(6):1104-1122.e9
S5484	Rimantadine Hydrochloride	Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.	bioRxiv, 2020, 2020.08.12.246389
S3168	cis-Resveratrol	cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
S4737	Psoralen	Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.	Metabolites, 2022, 13(1)3
E0488	BC-LI-0186	BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS, LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.	Cancer Res Treat, 2023, 55(3):851-864
S5953	Menadione bisulfite sodium	Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Life Sci, 2020, 242:117159
S7449	CRT0044876	CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.	Cell Rep, 2024, 43(10):114820 Nat Biotechnol, 2017, 35(5):463-474
S3549	PFM01	PFM01, a cell-permeable N-alkylated Mirin derivative, is a selective inhibitor of MRE11 endonuclease activity.	Cell Rep, 2023, 42(7):112792
S7637	DTP3	DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.	Life Sci Alliance, 2024, 7(8)e202302555 MedComm (2020), 2023, 4(3):e269
S1981	Adenine	Adenine(6-Aminopurine) is a purine derivative and a nucleobase with a variety of roles in biochemistry.	PLoS Pathog, 2020, 16;16(3):e1008341
S6854	Triazavirin (TZV)	Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.	Nature, 2022, 604(7904):120-126
S0469	ML216	ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM^636-1298 and BLM^full-length, respectively.	Elife, 2024, 13RP99026 Cells, 2022, 12(1)145
S3001	Clevudine	Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.	J Biomed Sci, 2024, 31(1):34
E2939	Didox	Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of resistant breast cancer cells.
S3009	Menthone	Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.
S3472	Metarrestin	Metarrestin is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
E1152	AGX51	AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization.
S8376	Rbin-1	Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.
S6909	Levomefolic acid	Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
E0459	Robinetin	Robinetin inhibits HIV integrase cleavage and integration in a dose-dependent manne, inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus, also inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.
E1596	AOH1996	AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.
S0816	Brr2 Inhibitor C9	Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders.
E1528^New	RP-6685	RP-6685 is a potent, selective, and orally active inhibitor of DNA polymerase theta (Polθ). RP-6685 exhibits antitumor efficacy in animal models.
S4888	Guanine	Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.
S9775	SCR130	SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.
S5813	Isoginkgetin	Isoginkgetin is a naturally derived biflavonoid with anti-tumor activity. Isoginkgetin directly inhibits the chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S proteasome. Isoginkgetin also is a general inhibitor of Pre-mRNA splicing.	Cell Death Dis, 2024, 15(4):289 Cell Death Dis, 2024, 15(4):289
S8328	CeMMEC1 HCl	CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).
S0054	D-I03	D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively.
S0063	RG3039	RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively.
S4504	6-Mercaptopurine (6-MP) Monohydrate	6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
S5505	2’-deoxyuridine	2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.
S9716^New	H3B-8800	H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations.
S0780	Oncrasin-1	Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells.
S6359	Purine	Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A.
S8942	Suramin sodium salt	Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).	J Biol Chem, 2024, S0021-9258(24)00128-5
S9286	Neobavaisoflavone	Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.
S6848	3'-Fluoro-3'-deoxythymidine (Alovudine)	3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
E0443	LDC195943 (IMT1)	LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
E0444	LDC203974 (IMT1B)	LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. LDC203974 has anti-tumour effects.
E1255	5-Ethynyluridine	5-Ethynyluridine (5-EU) is a cell-permeable nucleoside and can be used to label newly synthesized RNA.
S8964	Actinomycin D (Dactinomycin)	Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Mol Cancer, 2024, 23(1):186 Nat Commun, 2024, 15(1):5209 Exp Mol Med, 2024, 10.1038/s12276-024-01315-x
S9649	Acelarin (NUC-1031)	Acelarin (NUC-1031, CPF-31, MTL-007, GTPL7389) is a DNA synthesis inhibitor with EC50 of 0.2 nM.
E1331	SU056	SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells.	Cancer Lett, 2024, 602:217197 Transl Oncol, 2024, 45:101965
E1987^New	APX2009	APX2009 is a second-generation redox-specific inhibitor of APE1/Ref-1, an essential enzyme in the base excision repair (BER) pathway. APX2009 effectively reduces breast cancer cell proliferation and colony formation.
S0102	L 189	L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.
S9936	ART558	ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM.
S3641	Osalmid	Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
S3360	Bis(2-ethylhexyl) phthalate	Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.
S5293	Nimustine Hydrochloride	Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
S5297	Vidarabine monohydrate	Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.
S6997	CHAPS	CHAPS is a zwitterionic surfactant that decreases the sequence specificity of the nucleosome.
S1126^New	CX-3543(Quarfloxin)	Quarfloxin (CX-3543), a fluoroquinolone derivative inhibits RNA pol I activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.
E1111	VV116	VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM.
S6115	Pyridoxal 5′-phosphate hydrate	Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.
E2921	Diethyl Pyrocarbonate	Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues.
S3356	Phosphonoacetic acid	Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S8326	Saccharin 1-methylimidazole (SMI)	Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.
S0161	ML367	ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
S8977	BCH001	BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.
S5828	L-Abrine	L-Abrine (N-Methyl-L-tryptophan), an extremely toxic toxalbumin found in the seeds of the rosary pea, is a ribosome inhibiting protein.
S1982	Adenine sulfate	Adenine sulfate(Adenine hemisulfate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
E0510	Cidofovir hydrate	Cidofovir hydrate is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.
E1529	ART812	ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM.
S6077	Cytidine 5′-triphosphate (disodium salt)	Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases.
S9603	Lurbinectedin	Lurbinectedin, a DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
S6893	PIN1 inhibitor API-1	PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.
S4476	PCNA-I1	PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.
S4236	Proflavine Hemisulfate	Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
S5374	5'-Cytidylic acid	5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA.
S5384	UTP Trisodium Salt	Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.
S2600	Fexinidazole	Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).	Int J Mol Sci, 2024, 25(8)4413
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1
S4782	5-methoxyflavone	5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
S4537	Oxolinic acid	Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
S4423	Emamectin Benzoate	Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
E1070	Phen-DC3 Trifluoromethanesulfonate	Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.
S8329	CeMMEC13	CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).
E0511	Framycetin sulphate	Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM, and competes for specific divalent metal ion binding sites in RNase P RNA, also inhibits hammerhead ribozyme with a Ki of 13.5 μM.
S2427	Triglycidyl Isocyanurate (Teroxirone)	Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
S9382	Thymine	Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.
S1166	Cisplatin	Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Nat Cancer, 2024, 10.1038/s43018-024-00814-0 Nat Commun, 2024, 15(1):5775 Nat Commun, 2024, 15(1):2853
S7418	Cycloheximide	Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Signal Transduct Target Ther, 2024, 9(1):65 Mol Cancer, 2024, 23(1):143 Cell Metab, 2024, 36(7):1598-1618.e11
S1714	Gemcitabine	Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Drug Resist Updat, 2024, 74:101079 Nat Commun, 2024, 15(1):1287
S1209	5-FU (5-Fluorouracil)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Mol Cancer, 2024, 23(1):186 Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Cell Biol, 2024, 10.1038/s41556-024-01473-0
S1224	Oxaliplatin	Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Mol Cancer, 2024, 23(1):186 Mol Cancer, 2024, 23(1):23 Gastroenterology, 2024, S0016-5085(24)00062-3
S1491	Fludarabine	Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.	Nat Commun, 2024, 15(1):1718 Cell Rep Med, 2024, 5(2):101420 Cell Death Dis, 2024, 15(8):600
S1149	Gemcitabine HCl	Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.	Int J Biol Sci, 2024, 20(4):1389-1409 Phytomedicine, 2024, 155377 Cell Oncol (Dordr), 2024, 10.1007/s13402-024-00939-5
S1215	Carboplatin	Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Nat Commun, 2024, 15(1):1158 Cell Rep Med, 2024, S2666-3791(24)00201-5
S8146	Mitomycin C	Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Nucleic Acids Res, 2024, gkae740 Clin Transl Med, 2024, 14(2):e1586 J Neuroinflammation, 2024, 21(1):136
S1117	Triciribine (API-2)	Triciribine (API-2) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.	J Cell Sci, 2023, 136(4)jcs259788 Exp Gerontol, 2023, 173:112091 EJHaem, 2023, 4(3):631-638
S8932	Remdesivir (GS-5734)	Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.	Antiviral Res, 2024, 225:105840 Int J Mol Sci, 2024, 25(3)1427 Int J Mol Sci, 2024, 24;25(3):1427.
S1648	Cytarabine	Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.	Nat Commun, 2024, 15(1):4739 Blood Adv, 2024, 8(20):5315-5329 iScience, 2024, 27(1):108667
S3035	Daunorubicin HCl	Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with K_i of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.	Nat Commun, 2024, 15(1):4739 Haematologica, 2024, 109(6):1713-1725 Int J Oncol, 2024, 64(6)66
S2684	Pidnarulex (CX-5461)	Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.	Mol Cell, 2024, 84(8):1527-1540.e7 Cell Rep Med, 2024, 5(10):101778 Sci Rep, 2024, 14(1):4060
S1229	Fludarabine Phosphate	Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.	J Autoimmun, 2024, 149:103307 Cell Death Dis, 2024, 15(3):224 J Biomed Sci, 2022, 29(1):20
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375 Cancer Cell, 2022, 40(10):1128-1144.e8
S1896	Hydroxyurea	Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.	Nat Commun, 2024, 15(1):7360 iScience, 2024, 27(4):109580 Sci Adv, 2024, 10(21):eadk8908
S2794	Sofosbuvir	Sofosbuvir is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.	J Med Virol, 2024, 96(7):e29787 PLoS One, 2024, 19(5):e0303265 mBio, 2023, 10.1128/mbio.01318-23
S7742	SCR7	SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). It increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos.	iScience, 2024, 27(2):108814 Nat Commun, 2023, 14(1):4761 Nat Commun, 2023, 14(1):4761
S2239	Tubacin	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. Tubacin reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis.	Dev Cell, 2024, S1534-5807(24)00326-5 Br J Cancer, 2023, 10.1038/s41416-023-02195-0 Int J Mol Sci, 2023, 24(5)4720
S1156	Capecitabine	Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.	Genes Dis, 2024, 11(1):430-448 Naunyn Schmiedebergs Arch Pharmacol, 2024, 10.1007/s00210-024-03145-0 J Pers Med, 2022, 12(2)258
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.	Cancer Discov, 2024, 10.1158/2159-8290.CD-24-0887 Cell Rep Med, 2024, 5(7):101615 Mol Cancer Res, 2024, 22(1):82-93
S1373	Daptomycin	Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.	Molecules, 2023, 28(2)621 Infect Drug Resist, 2023, 16:4867-4879 Infect Drug Resist, 2023, 16:4867-4879
S1199	Cladribine	Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.	Oncotarget, 2024, 15:220-231 Exp Hematol Oncol, 2023, 12(1):23 Neurol Neuroimmunol Neuroinflamm, 2023, 10(5)e200149
S7419	Blasticidin S HCl	Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation. It is used to select transfected cells carrying bsr or BSD resistance genes.	Nucleic Acids Res, 2024, gkae787 Cell Rep Med, 2024, 5(5):101533 Pharmacol Res, 2024, 206:107283
S5582	Cytarabine hydrochloride	Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.	Blood, 2022, blood.2022016090 Clin Transl Med, 2022, 12(2):e722 Front Pharmacol, 2022, 13:1032975
S7975	Favipiravir (T-705)	Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.	J Med Virol, 2024, 96(1):e29372 Okayama University, 2023 , 10.18926/65391 Nat Commun, 2022, 13(1):2256
S1218	Clofarabine	Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.	Front Oncol, 2023, 13:1287444 Cancer Res, 2022, 82(4):721-733 Clin Transl Med, 2022, 12(2):e747
S8246	RK-33	RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.	Cell Rep, 2024, 43(3):113937 JCI Insight, 2023, 8(7)e167566 Mol Immunol, 2023, 154:54-60
S1302	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.	Cancer Res, 2023, 83(16):2750-2762 Comput Struct Biotechnol J, 2023, 21:3827-3840 Comput Struct Biotechnol J, 2023, 21:3827-3840
S1807	Acyclovir (Aciclovir)	Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.	Cell, 2023, 186(14):3033-3048.e20 iScience, 2022, 25(12):105682 Pharmaceutics, 2022, 14(3)536
S1289	Carmofur	Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.	JCI Insight, 2023, 8(9)e166850 Cell Death Discov, 2023, 9(1):451 Int J Mol Sci, 2023, 24(7)6062
S7470	Triapine (3-AP)	Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.	J Virol, 2023, 97(8):e0026723 Res Sq, 2023, rs.3.rs-3126261 Cancer Res, 2022, 82(4):721-733
S1192	Raltitrexed	Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	Mol Ther, 2022, S1525-0016(22)00717-1 ACS Chem Neurosci, 2022, 13(17):2646-2657 Biochem Biophys Res Commun, 2022, 610:1-7
S1221	Dacarbazine	Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.	Cell Death Dis, 2023, 14(6):348 BMC Complement Med Ther, 2023, 23(1):111 BMC Complement Med Ther, 2023, 23(1):111
S1305	Mercaptopurine (6-MP)	Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.	Nat Commun, 2023, 14(1):5913 Nat Commun, 2023, 14(1):5913 J Pers Med, 2022, 12(2)258
S8434	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).	iScience, 2024, 27(2):108814 Cell Prolif, 2023, 56(4):e13384 Cancer Med, 2023, 12(6):6594-6602
S7718	BMH-21	BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.	Nucleic Acids Res, 2024, gkae316 Elife, 2024, 13e80684 J Biol Chem, 2024, 300(3):107115
S1213	Nelarabine	Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.	Cancer Res, 2022, 82(4):721-733 Cell Rep, 2022, 39(10):110913 J Pers Med, 2022, 12(2)258
S7679	YK-4-279	YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).	Nat Commun, 2024, 15(1):4590 Cancers -Basel), 2023, 15(19)4772 Cell Chem Biol, 2022, 29(8):1325-1332.e4
S1764	Rifampin (Rifampicin)	Rifampin (Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.	Cell Death Dis, 2023, 14(1):64 Int J Mol Sci, 2022, 23(13)7383 Biomedicines, 2021, 9(8)996
S1299	Floxuridine (FUDR)	Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Cell Chem Biol, 2021, S2451-9456(21)00306-8
S1949	Menadione (Vitamin K3)	Menadione (Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Med -N Y, 2022, S2666-6340-2200365-8 Mol Cell, 2021, S1097-2765(21)00269-0 DNA Repair (Amst), 2021, 105:103152
S1995	Procarbazine HCl	Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S4239	Bergapten	Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00579-z
S4288	Chloroambucil	Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.	bioRxiv, 2023, 2023.01.17.524444 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S1516	Cidofovir	Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.	Oncol Lett, 2021, 21(4):280 Nat Biotechnol, 2019, 37(3):303-313 Antiviral Res, 2019, 162:178-185
S2678	NSC 207895	NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.	PLoS One, 2024, 19(1):e0295629 Front Oncol, 2021, 11:582511 Genes Dev, 2020, 34(7-8):526-543
S1778	Trifluridine (NSC 75520)	Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.	Nat Med, 2023, 29(3):605-614 JCI Insight, 2022, 7(22e158060) Biochem Biophys Res Commun, 2022, 610:119-126
S1300	Tegafur (FT-207)	Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer.	J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 34(6):1911-1918
S8144	Halofuginone	Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.	Cell Rep, 2024, 43(9):114728 J Neurochem, 2024, 10.1111/jnc.16102 Infect Agent Cancer, 2023, 18(1):27
S4227	Fidaxomicin	Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.	J Antimicrob Chemother, 2024, dkae101 Nucleic Acids Res, 2023, 51(19):e99 bioRxiv, 2023, 2023.03.13.532464
S1384	Mizoribine	Mizoribine is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.	EMBO J, 2023, e110620. bioRxiv, 2022, 2021.07.02.450964 Cell Death Differ, 2021, 10.1038/s41418-021-00853-5
S4297	Mupirocin	Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.	Infect Drug Resist, 2023, 16:4867-4879 Infect Drug Resist, 2023, 16:4867-4879 Anaerobe, 2020, 62:102169
S1217	Cyclophosphamide	Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.	J Immunother, 2024, 10.1097/CJI.0000000000000505 Oncol Lett, 2024, 27(4):158 Stem Cell Res Ther, 2023, 14(1):75
S1973	Cyclocytidine HCl	Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.	Transl Oncol, 2023, 35:101712 PeerJ, 2022, 10:e13719 Acta Biochim Biophys Sin (Shanghai), 2020, 14 pii: gmaa017
S5948	Amodiaquine	Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.	Molecules, 2024, 29(6)1363 Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9 bioRxiv, 2020, 10.1101/2020.04.13.039917
S1907	Metronidazole	Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.	Microorganisms, 2022, 10(7)1421 Elife, 2021, 10e69795 Bone Joint Res, 2020, 16;9(4):152-161
S1760	Rifapentine	Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.	Int J Mol Sci, 2022, 23(13)7383 Front Microbiol, 2020, 10:2936 mSphere, 2018, 3(5)
S1784	Vidarabine	Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.	Neuron, 2017, 96(6):1290-1302 ACS Appl Mater Interfaces, 2016, 8(39):25818-25824 Biogerontology, 2016, 17(5-6):907-920
S1826	Nedaplatin	Nedaplatin(NSC 375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Nat Commun, 2019, 10(1):5654 Cancer Res, 2018, 78(19):5694-5705 Oncol Lett, 2016, 12(5):4195-4202
S7445	APX-3330	APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.	J Transl Med, 2023, 21(1):183 Cell Death Dis, 2022, 13(2):124 Cancer Research on Prevention and Treatment, 2020, (7): 492-497
S7757	6-Thio-dG	6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.	Cell Death Discov, 2024, 10(1):381 Radiation Medicine and Protection, 2022, 64-71 Clin Sci (Lond), 2020, 10.1042/CS20190890
S9521	Pentostatin	Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.	Res Sq, 2023, rs.3.rs-2276903 Nat Metab, 2020, 10.1038/s42255-020-0227-4
S8539	TAS-102	TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.	STAR Protoc, 2024, 5(2):103090 J Exp Clin Cancer Res, 2023, 42(1):8 Adv Sci (Weinh), 2021, e2103360
S3669	Carmustine	Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Cancer Res, 2021, 81(23):6044-6057
S8850	JH-RE-06	JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).	Nucleic Acids Res, 2024, gkae317 Nucleic Acids Res, 2024, gkae785 Cell Rep, 2024, 43(5):114205
S7546	Pritelivir (BAY 57-1293)	Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.	PLoS Pathog, 2021, 17(11):e1010117 J Virol, 2021, JVI0166621
S9718	TK216	TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.	J Biol Chem, 2024, 300(6):107375 Sci Rep, 2023, 13(1):14360 Sci Rep, 2023, 13(1):14360
S1790	Rifaximin	Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.	Int J Mol Sci, 2022, 23(13)7383
S5552	Amenamevir	Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.	J Biomol Struct Dyn, 2020, 1-14
S0280	Madrasin	Madrasin (DDD00107587) is a potent and cell-penetrant pre-mRNA splicing inhibitor. Madrasin interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.	Leukemia, 2023, 37(8):1649-1659
S8095	Tubercidin	Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.	Mol Cell, 2020, 80(6):1104-1122.e9
S5484	Rimantadine Hydrochloride	Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.	bioRxiv, 2020, 2020.08.12.246389
S3168	cis-Resveratrol	cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.	J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493
S4737	Psoralen	Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.	Metabolites, 2022, 13(1)3
E0488	BC-LI-0186	BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS, LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.	Cancer Res Treat, 2023, 55(3):851-864
S5953	Menadione bisulfite sodium	Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Life Sci, 2020, 242:117159
S7449	CRT0044876	CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.	Cell Rep, 2024, 43(10):114820 Nat Biotechnol, 2017, 35(5):463-474
S3549	PFM01	PFM01, a cell-permeable N-alkylated Mirin derivative, is a selective inhibitor of MRE11 endonuclease activity.	Cell Rep, 2023, 42(7):112792
S7637	DTP3	DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.	Life Sci Alliance, 2024, 7(8)e202302555 MedComm (2020), 2023, 4(3):e269
S6854	Triazavirin (TZV)	Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.	Nature, 2022, 604(7904):120-126
S0469	ML216	ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM^636-1298 and BLM^full-length, respectively.	Elife, 2024, 13RP99026 Cells, 2022, 12(1)145
S3001	Clevudine	Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.	J Biomed Sci, 2024, 31(1):34
E2939	Didox	Didox (3,4-dihydroxy-benzohydroxamic acid) is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of resistant breast cancer cells.
S3009	Menthone	Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.
S3472	Metarrestin	Metarrestin is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
E1152	AGX51	AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization.
S8376	Rbin-1	Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.
E0459	Robinetin	Robinetin inhibits HIV integrase cleavage and integration in a dose-dependent manne, inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus, also inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.
E1596	AOH1996	AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.
S0816	Brr2 Inhibitor C9	Brr2 inhibitor C9 (Brr2 Inhibitor 9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders.
E1528^New	RP-6685	RP-6685 is a potent, selective, and orally active inhibitor of DNA polymerase theta (Polθ). RP-6685 exhibits antitumor efficacy in animal models.
S9775	SCR130	SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.
S5813	Isoginkgetin	Isoginkgetin is a naturally derived biflavonoid with anti-tumor activity. Isoginkgetin directly inhibits the chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S proteasome. Isoginkgetin also is a general inhibitor of Pre-mRNA splicing.	Cell Death Dis, 2024, 15(4):289 Cell Death Dis, 2024, 15(4):289
S8328	CeMMEC1 HCl	CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).
S0054	D-I03	D-I03 is a selective inhibitor of RAD52 with Kd of 25.8 µM. D-I03 inhibits ssDNA annealing by RAD52 and D-loop formation with IC50 of 5 µM and 8 µM, respectively.
S0063	RG3039	RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively.
S4504	6-Mercaptopurine (6-MP) Monohydrate	6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
S0780	Oncrasin-1	Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells.
S8942	Suramin sodium salt	Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).	J Biol Chem, 2024, S0021-9258(24)00128-5
S9286	Neobavaisoflavone	Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.
S6848	3'-Fluoro-3'-deoxythymidine (Alovudine)	3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
E0443	LDC195943 (IMT1)	LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
E0444	LDC203974 (IMT1B)	LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. LDC203974 has anti-tumour effects.
S8964	Actinomycin D (Dactinomycin)	Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Mol Cancer, 2024, 23(1):186 Nat Commun, 2024, 15(1):5209 Exp Mol Med, 2024, 10.1038/s12276-024-01315-x
S9649	Acelarin (NUC-1031)	Acelarin (NUC-1031, CPF-31, MTL-007, GTPL7389) is a DNA synthesis inhibitor with EC50 of 0.2 nM.
E1331	SU056	SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells.	Cancer Lett, 2024, 602:217197 Transl Oncol, 2024, 45:101965
E1987^New	APX2009	APX2009 is a second-generation redox-specific inhibitor of APE1/Ref-1, an essential enzyme in the base excision repair (BER) pathway. APX2009 effectively reduces breast cancer cell proliferation and colony formation.
S0102	L 189	L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.
S9936	ART558	ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM.
S3641	Osalmid	Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
S3360	Bis(2-ethylhexyl) phthalate	Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.
S5293	Nimustine Hydrochloride	Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.
S5297	Vidarabine monohydrate	Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.
S1126^New	CX-3543(Quarfloxin)	Quarfloxin (CX-3543), a fluoroquinolone derivative inhibits RNA pol I activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.
E1111	VV116	VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM.
S6115	Pyridoxal 5′-phosphate hydrate	Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.
E2921	Diethyl Pyrocarbonate	Diethyl pyrocarbonate is a potent, non-specific inhibitor of RNase. It has been useful as an in vitro agent, relatively specific for binding to imidazole of histidine. It inhibits central chemosensitivity in rabbit and can modify Ser, Thr, His and Tyr residues.
S3356	Phosphonoacetic acid	Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
S0161	ML367	ML367 is a potent, micromolar inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization. ML367 blocks DNA repair pathways and general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
S8977	BCH001	BCH001 is a specific PAPD5 inhibitor that restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells. PAPD5 is a noncanonical poly(A) polymerase with an unusual RNA-binding motif.
E0510	Cidofovir hydrate	Cidofovir hydrate is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.
E1529	ART812	ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM.
S4236	Proflavine Hemisulfate	Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.
S2600	Fexinidazole	Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).	Int J Mol Sci, 2024, 25(8)4413
S2961	GC7 Sulfate	GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	Exp Mol Med, 2024, 10.1038/s12276-024-01214-1
S4782	5-methoxyflavone	5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
S4537	Oxolinic acid	Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
E1070	Phen-DC3 Trifluoromethanesulfonate	Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65 ± 6 and 50 ± 10 nM, respectively.
S8329	CeMMEC13	CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).
E0511	Framycetin sulphate	Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM, and competes for specific divalent metal ion binding sites in RNase P RNA, also inhibits hammerhead ribozyme with a Ki of 13.5 μM.
S2427	Triglycidyl Isocyanurate (Teroxirone)	Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
S8326	Saccharin 1-methylimidazole (SMI)	Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.
S6893	PIN1 inhibitor API-1	PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.
S4476	PCNA-I1	PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.
S4423	Emamectin Benzoate	Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.
S1334	Flupirtine maleate	Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.	Assay Drug Dev Technol, 2019, 17(7):310-321 Elife, 2015, 4
S6909	Levomefolic acid	Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
S9716^New	H3B-8800	H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations.
S6997	CHAPS	CHAPS is a zwitterionic surfactant that decreases the sequence specificity of the nucleosome.
S9603	Lurbinectedin	Lurbinectedin, a DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. Lurbinectedin inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively.
E1528^New	RP-6685	RP-6685 is a potent, selective, and orally active inhibitor of DNA polymerase theta (Polθ). RP-6685 exhibits antitumor efficacy in animal models.
S9716^New	H3B-8800	H3B-8800 is a potent and orally active modulator of SF3B splicing. H3B-8800 interacts directly with the SF3b complex, demonstrating anti-cancer properties. H3B-8800 holds promise for studying acute myeloid leukemia (AML) with SF3B1 mutations.
E1987^New	APX2009	APX2009 is a second-generation redox-specific inhibitor of APE1/Ref-1, an essential enzyme in the base excision repair (BER) pathway. APX2009 effectively reduces breast cancer cell proliferation and colony formation.
S1126^New	CX-3543(Quarfloxin)	Quarfloxin (CX-3543), a fluoroquinolone derivative inhibits RNA pol I activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.

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